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POLE2 DNA polymerase epsilon 2, accessory subunit [ Bos taurus (domestic cattle) ]

Gene ID: 518653, updated on 4-Oct-2024

Summary

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Official Symbol
POLE2provided by VGNC
Official Full Name
DNA polymerase epsilon 2, accessory subunitprovided by VGNC
Primary source
VGNC:VGNC:33119
See related
BGD:BT10249; Ensembl:ENSBTAG00000004931
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See POLE2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (42673754..42705627, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene dynein axonemal assembly factor 2 Neighboring gene microRNA mir-6517 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene kelch domain containing 1 Neighboring gene kelch domain containing 2 Neighboring gene small nucleolar RNA SNORA11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC157096

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase epsilon subunit 2
Names
DNA polymerase II subunit 2
DNA polymerase epsilon subunit B
DNA-directed DNA polymerase epsilon 2
polymerase (DNA directed), epsilon 2 (p59 subunit)
polymerase (DNA directed), epsilon 2, accessory subunit
NP_001098853.1
XP_010807554.2
XP_010807555.2
XP_010807556.1
XP_010807559.2
XP_024853307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105383.2 → NP_001098853.1  DNA polymerase epsilon subunit 2

    See identical proteins and their annotated locations for NP_001098853.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134762
    UniProtKB/Swiss-Prot
    A7YWS7
    UniProtKB/TrEMBL
    A0AAA9SXI1
    Related
    ENSBTAP00000006488.7, ENSBTAT00000006488.7
    Conserved Domains (2) summary
    pfam04042
    Location:288 → 488
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:3 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42673754..42705627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997539.2 → XP_024853307.1  DNA polymerase epsilon subunit 2 isoform X4

    UniProtKB/TrEMBL
    A0AAA9TF96
    Conserved Domains (1) summary
    pfam04042
    Location:228 → 428
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

  2. XM_010809253.4 → XP_010807555.2  DNA polymerase epsilon subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0AAA9TF96
    Conserved Domains (2) summary
    pfam04042
    Location:288 → 487
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:4 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal

  3. XM_010809252.4 → XP_010807554.2  DNA polymerase epsilon subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TF96
    Related
    ENSBTAP00000094823.1, ENSBTAT00000114252.1
    Conserved Domains (2) summary
    pfam04042
    Location:288 → 488
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:4 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal

  4. XM_010809257.4 → XP_010807559.2  DNA polymerase epsilon subunit 2 isoform X4

    UniProtKB/TrEMBL
    A0AAA9TF96
    Conserved Domains (1) summary
    pfam04042
    Location:228 → 428
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

  5. XM_010809254.4 → XP_010807556.1  DNA polymerase epsilon subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_010807556.1

    UniProtKB/TrEMBL
    A0AAA9SXI1
    Conserved Domains (2) summary
    pfam04042
    Location:288 → 487
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:3 → 73
    Dpoe2NT; DNA polymerases epsilon N terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7YWS7.1 GenPept UniProtKB/Swiss-Prot:A7YWS7

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