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GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 51809, updated on 3-Apr-2024

Summary

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Official Symbol
GALNT7provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4129
See related
Ensembl:ENSG00000109586 MIM:605005; AllianceGenome:HGNC:4129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GalNAcT7; GALNAC-T7
Summary
This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 19.2), colon (RPKM 18.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
4q34.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173168811..173323967)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176508240..176663390)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174089962..174245118)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase like 6 Neighboring gene uncharacterized LOC107986201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:173896580-173897080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22153 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:173991635-173992284 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:173994926-173995724 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:173995725-173996523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174004943-174005676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15803 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15805 Neighboring gene GALNT7 divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 253, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174147822-174148337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174147305-174147821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22156 Neighboring gene uncharacterized LOC124900812 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:174196465-174196667 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:174227831-174228613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:174228614-174229395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15809 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174255709-174256444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22158 Neighboring gene microRNA 548t Neighboring gene SAP30 divergent transcript Neighboring gene high mobility group box 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Scott E, et al. Oncogene, 2023 Mar. PMID 36725887, Free PMC Article
  2. Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7. Yu C, et al. Biochem Biophys Res Commun, 2019 Mar 5. PMID 30685086
  3. A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. Bennett EP, et al. FEBS Lett, 1999 Oct 29. PMID 10544240
  4. MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7. Gao F, et al. Genes Genomics, 2023 Feb. PMID 36040682
  5. miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer. Lu Q, et al. Tumour Biol, 2016 Nov. PMID 27619677

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of O-linked glycosyltransferase GALNT7 in breast cancer is dependent on estrogen-, progesterone-, and HER2-receptor status, with prognostic implications.
    Title: The expression of O-linked glycosyltransferase GALNT7 in breast cancer is dependent on estrogen-, progesterone-, and HER2-receptor status, with prognostic implications.
  2. SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.
    Title: SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.
  3. Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.
    Title: Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.
  4. MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7.
    Title: MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7.
  5. Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by sponging the miR-103a/GALNT7 pathway.
    Title: Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by sponging the miR-103a/GALNT7 pathway.
  6. Results indicated that SNHG7 facilitated the proliferation and metastasis as a competing endogenous RNA to regulate GALNT7 expression by sponging miR-34a in CRC cell lines.
    Title: Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
  7. crystallographic analysis of GalNAc-T7, a GalNAc-T capable of glycosylating consecutive sites, and of its complex with the donor substrate UDP-GalNAc
    Title: Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7.
  8. miR-494 and GALNT7 play oncogenic roles in nasopharyngeal carcinoma.
    Title: GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.
  9. High expression of GALNT7 promotes migration and invasion and lymph node metastasis in esophageal squamous cell carcinoma.
    Title: miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer.
  10. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC
    Title: Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
  
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
N-acetylgalactosaminyltransferase 7
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
polypeptide GalNAc transferase 7
pp-GaNTase 7
protein-UDP acetylgalactosaminyltransferase 7
NP_001362528.1
NP_001362529.1
NP_001362530.1
NP_059119.2
XP_011530327.1
XP_016863781.1
XP_047271734.1
XP_047271735.1
XP_047271736.1
XP_047271737.1
XP_047271738.1
XP_054206155.1
XP_054206156.1
XP_054206157.1
XP_054206158.1
XP_054206159.1
XP_054206160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375599.1 → NP_001362528.1  N-acetylgalactosaminyltransferase 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
    Consensus CDS
    CCDS93669.1
    UniProtKB/TrEMBL
    H0YAH3
    Related
    ENSP00000427095.2, ENST00000505308.6
    Conserved Domains (2) summary
    cd02510
    Location:210 → 518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:534 → 649
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001375600.1 → NP_001362529.1  N-acetylgalactosaminyltransferase 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
    Conserved Domains (2) summary
    cd02510
    Location:210 → 518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:533 → 616
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_001375601.1 → NP_001362530.1  N-acetylgalactosaminyltransferase 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
    Conserved Domains (2) summary
    pfam00652
    Location:407 → 522
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:210 → 391
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. NM_017423.3 → NP_059119.2  N-acetylgalactosaminyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_059119.2

    Status: REVIEWED

    Source sequence(s)
    AJ002744, BC035303, BC046129, BC047468
    Consensus CDS
    CCDS3815.1
    UniProtKB/Swiss-Prot
    B3KQU3, Q7Z5W7, Q86SF2, Q9UJ28
    Related
    ENSP00000265000.4, ENST00000265000.9
    Conserved Domains (2) summary
    cd02510
    Location:210 → 518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:534 → 649
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    173168811..173323967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415780.1 → XP_047271736.1  N-acetylgalactosaminyltransferase 7 isoform X1

  2. XM_047415779.1 → XP_047271735.1  N-acetylgalactosaminyltransferase 7 isoform X2

  3. XM_047415778.1 → XP_047271734.1  N-acetylgalactosaminyltransferase 7 isoform X1

  4. XM_011532025.4 → XP_011530327.1  N-acetylgalactosaminyltransferase 7 isoform X3

    Conserved Domains (4) summary
    cd02510
    Location:169 → 477
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:169 → 290
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:494 → 610
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:493 → 608
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  5. XM_047415782.1 → XP_047271738.1  N-acetylgalactosaminyltransferase 7 isoform X4

  6. XM_047415781.1 → XP_047271737.1  N-acetylgalactosaminyltransferase 7 isoform X3

  7. XM_017008292.3 → XP_016863781.1  N-acetylgalactosaminyltransferase 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    176508240..176663390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350183.1 → XP_054206158.1  N-acetylgalactosaminyltransferase 7 isoform X1

  2. XM_054350184.1 → XP_054206159.1  N-acetylgalactosaminyltransferase 7 isoform X3

  3. XM_054350181.1 → XP_054206156.1  N-acetylgalactosaminyltransferase 7 isoform X1

  4. XM_054350182.1 → XP_054206157.1  N-acetylgalactosaminyltransferase 7 isoform X1

  5. XM_054350185.1 → XP_054206160.1  N-acetylgalactosaminyltransferase 7 isoform X4

  6. XM_054350180.1 → XP_054206155.1  N-acetylgalactosaminyltransferase 7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86SF2.1 GenPept UniProtKB/Swiss-Prot:Q86SF2

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