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Srrm1 serine/arginine repetitive matrix 1 [ Mus musculus (house mouse) ]

Gene ID: 51796, updated on 2-Nov-2024

Summary

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Official Symbol
Srrm1provided by MGI
Official Full Name
serine/arginine repetitive matrix 1provided by MGI
Primary source
MGI:MGI:1858303
See related
Ensembl:ENSMUSG00000028809 AllianceGenome:MGI:1858303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POP101; Srm160
Summary
Predicted to enable DNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA splicing, via spliceosome. Part of spliceosomal complex. Is expressed in central nervous system; genitourinary system; pancreas epithelium; and sensory organ. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 32.0), CNS E11.5 (RPKM 29.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Srrm1 in Genome Data Viewer
Location:
4 D3; 4 67.34 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135047795..135080787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135320484..135353277, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11711 Neighboring gene predicted gene, 30701 Neighboring gene STARR-positive B cell enhancer ABC_E10266 Neighboring gene predicted gene 12984 Neighboring gene STARR-positive B cell enhancer ABC_E6233 Neighboring gene noncompact myelin associated protein Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A coactivator of pre-mRNA splicing. Blencowe BJ, et al. Genes Dev, 1998 Apr 1. PMID 9531537, Free PMC Article
  2. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
  3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing, via transesterification reactions ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/arginine repetitive matrix protein 1
Names
Ser/Arg-related nuclear matrix protein
plenty-of-prolines-101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130477.2 → NP_001123949.1  serine/arginine repetitive matrix protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) lacks 5 amino acids in the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL627078, AL627185
    Consensus CDS
    CCDS51329.1
    UniProtKB/TrEMBL
    A2A8V9, E9QKA4
    Related
    ENSMUSP00000081906.6, ENSMUST00000084846.12
    Conserved Domains (2) summary
    pfam00906
    Location:621 → 712
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  2. NM_001369067.1 → NP_001355996.1  serine/arginine repetitive matrix protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:623 → 820
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  3. NM_001369068.1 → NP_001355997.1  serine/arginine repetitive matrix protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:622 → 819
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  4. NM_001369069.1 → NP_001355998.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:611 → 806
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  5. NM_001369070.1 → NP_001355999.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    Consensus CDS
    CCDS89844.1
    UniProtKB/TrEMBL
    A2A8V8, E9QKA4
    Related
    ENSMUSP00000101487.2, ENSMUST00000105861.8
    Conserved Domains (2) summary
    PHA03247
    Location:389 → 805
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  6. NM_001369071.1 → NP_001356000.1  serine/arginine repetitive matrix protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:389 → 804
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  7. NM_001369072.1 → NP_001356001.1  serine/arginine repetitive matrix protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:594 → 791
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  8. NM_001369073.1 → NP_001356002.1  serine/arginine repetitive matrix protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:389 → 775
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  9. NM_001369074.1 → NP_001356003.1  serine/arginine repetitive matrix protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL627078, AL627185
    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:511 → 708
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  10. NM_016799.4 → NP_058079.2  serine/arginine repetitive matrix protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL627078, AL627185
    Consensus CDS
    CCDS38919.2
    UniProtKB/TrEMBL
    E9PUK6, E9QKA4
    Related
    ENSMUSP00000125003.2, ENSMUST00000136342.9
    Conserved Domains (2) summary
    pfam00906
    Location:626 → 717
    Hepatitis_core; Hepatitis core antigen
    pfam01480
    Location:46 → 115
    PWI; PWI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135047795..135080787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164230.1 → XP_036020123.1  serine/arginine repetitive matrix protein 1 isoform X8

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:589 → 786
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  2. XM_030253660.2 → XP_030109520.1  serine/arginine repetitive matrix protein 1 isoform X7

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:593 → 790
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  3. XM_030253661.2 → XP_030109521.1  serine/arginine repetitive matrix protein 1 isoform X9

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:359 → 775
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  4. XM_036164229.1 → XP_036020122.1  serine/arginine repetitive matrix protein 1 isoform X6

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:593 → 790
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  5. XM_030253657.2 → XP_030109517.1  serine/arginine repetitive matrix protein 1 isoform X2

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:618 → 815
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  6. XM_030253669.2 → XP_030109529.1  serine/arginine repetitive matrix protein 1 isoform X18

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:384 → 799
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  7. XM_030253659.2 → XP_030109519.1  serine/arginine repetitive matrix protein 1 isoform X5

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:384 → 800
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  8. XM_006539029.4 → XP_006539092.1  serine/arginine repetitive matrix protein 1 isoform X4

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:609 → 809
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  9. XM_030253658.2 → XP_030109518.1  serine/arginine repetitive matrix protein 1 isoform X3

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:609 → 806
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  10. XM_006539026.4 → XP_006539089.1  serine/arginine repetitive matrix protein 1 isoform X1

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:623 → 820
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46 → 115
    PWI; PWI domain

  11. XM_030253664.2 → XP_030109524.1  serine/arginine repetitive matrix protein 1 isoform X13

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:536 → 733
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  12. XM_006539033.4 → XP_006539096.1  serine/arginine repetitive matrix protein 1 isoform X10

    See identical proteins and their annotated locations for XP_006539096.1

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:541 → 738
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  13. XM_030253667.2 → XP_030109527.1  serine/arginine repetitive matrix protein 1 isoform X17

    Conserved Domains (1) summary
    PHA03247
    Location:109 → 347
    PHA03247; large tegument protein UL36; Provisional

  14. XM_030253665.2 → XP_030109525.1  serine/arginine repetitive matrix protein 1 isoform X15

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:510 → 707
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  15. XM_036164232.1 → XP_036020125.1  serine/arginine repetitive matrix protein 1 isoform X16

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03247
    Location:276 → 692
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  16. XM_017320313.3 → XP_017175802.1  serine/arginine repetitive matrix protein 1 isoform X14

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:511 → 708
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  17. XM_030253663.2 → XP_030109523.1  serine/arginine repetitive matrix protein 1 isoform X13

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:536 → 733
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  18. XM_030253662.2 → XP_030109522.1  serine/arginine repetitive matrix protein 1 isoform X12

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:540 → 737
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  19. XM_036164231.1 → XP_036020124.1  serine/arginine repetitive matrix protein 1 isoform X11

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:540 → 737
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  20. XM_006539032.5 → XP_006539095.1  serine/arginine repetitive matrix protein 1 isoform X10

    See identical proteins and their annotated locations for XP_006539095.1

    UniProtKB/TrEMBL
    E9QKA4
    Conserved Domains (2) summary
    PHA03307
    Location:541 → 738
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:1 → 32
    PWI; PWI domain

  21. XM_030253666.2 → XP_030109526.1  serine/arginine repetitive matrix protein 1 isoform X17

    Conserved Domains (1) summary
    PHA03247
    Location:109 → 347
    PHA03247; large tegument protein UL36; Provisional

  22. XM_030253668.2 → XP_030109528.1  serine/arginine repetitive matrix protein 1 isoform X17

    Conserved Domains (1) summary
    PHA03247
    Location:109 → 347
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_004941933.1 RNA Sequence

  2. XR_004941932.1 RNA Sequence

  3. XR_003954981.2 RNA Sequence

  4. XR_004941935.1 RNA Sequence

  5. XR_004941934.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KI8.2 GenPept UniProtKB/Swiss-Prot:Q52KI8

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