PDHX pyruvate dehydrogenase complex component X [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PDHXprovided by VGNC
Official Full Name: pyruvate dehydrogenase complex component Xprovided by VGNC
Primary source: VGNC:VGNC:32695
See related: BGD:BT22603; Ensembl:ENSBTAG00000018261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (65427257..65502625)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.
Title: Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
part_of pyruvate dehydrogenase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pyruvate dehydrogenase protein X component

Names: E3-binding protein; E3BP; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; proX; pyruvate dehydrogenase protein X component-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075751.1 → NP_001069219.1 pyruvate dehydrogenase protein X component precursor

See identical proteins and their annotated locations for NP_001069219.1

Status: PROVISIONAL

Source sequence(s)

BC120413

UniProtKB/Swiss-Prot

P22439, Q0P576

UniProtKB/TrEMBL

A0A3Q1N235, A0AAA9SZM1

Related

ENSBTAP00000024307.5, ENSBTAT00000024307.6

Conserved Domains (4) summary

cd06849
Location:57 → 131

lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...

TIGR01349
Location:58 → 500

PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam00198
Location:291 → 500

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

pfam02817
Location:183 → 215

E3_binding; e3 binding domain