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CAB39 calcium binding protein 39 [ Homo sapiens (human) ]

Gene ID: 51719, updated on 3-Nov-2024

Summary

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Official Symbol
CAB39provided by HGNC
Official Full Name
calcium binding protein 39provided by HGNC
Primary source
HGNC:HGNC:20292
See related
Ensembl:ENSG00000135932 MIM:612174; AllianceGenome:HGNC:20292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MO25; CGI-66
Summary
Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Part of cytoplasm and serine/threonine protein kinase complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues See more
Orthologs
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Genomic context

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See CAB39 in Genome Data Viewer
Location:
2q37.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230712842..230821075)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (231195928..231304198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231577557..231685790)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17232 Neighboring gene RNA, U6 small nuclear 451, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17236 Neighboring gene CRISPRi-validated cis-regulatory element chr2.6880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231524789-231525345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17241 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231531133-231531998 Neighboring gene Sharpr-MPRA regulatory region 12127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17247 Neighboring gene formin-like protein 16 Neighboring gene long intergenic non-protein coding RNA 1907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231585879-231586402 Neighboring gene BANF1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17248 Neighboring gene RNA, U6 small nuclear 268, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231654665-231655164 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:231657991-231659190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:231708391-231709016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231726605-231727215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231728341-231728999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231729658-231730316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231730317-231730973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734265-231734922 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734923-231735580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231742513-231743287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231757691-231758270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231758271-231758850 Neighboring gene integral membrane protein 2C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12419 Neighboring gene GPR55 cis regulatory suppressor of immune response RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39.
    Title: miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39.
  2. CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
    Title: CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
  3. miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.
    Title: miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.
  4. MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
    Title: MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
  5. miR-1265 suppresses gastric cancer progression and oncogenic autophagy by reducing CAB39 expression and regulating the AMPK-mTOR signaling pathway.
    Title: MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.
  6. The MO25 binding to SPAK and OSR1 is enhanced by serine phosphorylation in their highly conserved WEWS motif, which is located in their C-terminal domains.
    Title: C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.
  7. Upregulation of miR-451 expression suppressed the growth and invasion of glioma cells in vitro and in vivo by targeting CAB39 and modulating the mTOR/HIF-1a/VEGF signaling pathway.
    Title: MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.
  8. plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK signaling pathway
    Title: Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.
  9. These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases.
    Title: Structural insights into the activation of MST3 by MO25.
  10. Authors conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly.
    Title: MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular hypotonic response IC
Inferred by Curator
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of potassium ion transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity IC
Inferred by Curator
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to thyroid hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  
part_of serine/threonine protein kinase complex IC
Inferred by Curator
more info
 PubMed 
part_of serine/threonine protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of serine/threonine protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calcium-binding protein 39
Names
MO25alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130849.2 → NP_001124321.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, AK292382
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000386238.3, ENST00000409788.7
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

  2. NM_001130850.2 → NP_001124322.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AC084031, AF113536, AK000804, AK315692, DB455871
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000386642.3, ENST00000410084.7
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

  3. NM_016289.4 → NP_057373.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_057373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents an alternate non-coding exon in the 5'UTR. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, BC020570, BG773506, DA886579
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000258418.5, ENST00000258418.10
    Conserved Domains (1) summary
    pfam08569
    Location:5 → 334
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230712842..230821075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007076406.1 RNA Sequence

  2. XR_007076407.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    231195928..231304198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486418.1 RNA Sequence

  2. XR_008486419.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y376.1 GenPept UniProtKB/Swiss-Prot:Q9Y376

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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