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OAZ3 ornithine decarboxylase antizyme 3 [ Homo sapiens (human) ]

Gene ID: 51686, updated on 5-Mar-2024

Summary

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Official Symbol
OAZ3provided by HGNC
Official Full Name
ornithine decarboxylase antizyme 3provided by HGNC
Primary source
HGNC:HGNC:8097
See related
Ensembl:ENSG00000143450 MIM:605138; AllianceGenome:HGNC:8097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ3; OAZ-t; TISP15
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Biased expression in testis (RPKM 63.7) and prostate (RPKM 6.3) See more
Orthologs
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Genomic context

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Location:
1q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151762969..151771330)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150886358..150894807)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151735445..151743806)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 662, pseudogene Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1724 Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151741546-151742242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151742243-151742937 Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1326 Neighboring gene TDRKH antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. Christensen GL, et al. BMC Med Genet, 2006 Mar 16. PMID 16542438, Free PMC Article
  2. Regulation of all members of the antizyme family by antizyme inhibitor. Mangold U, et al. Biochem J, 2005 Jan 1. PMID 15355308, Free PMC Article
  3. Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. Ivanov IP, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781085, Free PMC Article
  4. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. Snapir Z, et al. Biochem J, 2008 Mar 15. PMID 18062773
  5. Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. Guo X, et al. J Neurobiol, 2001 Aug. PMID 11438941

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3.
  2. Mutations in the OAZ3 gene are not a common cause of male infertility.
    Title: Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3.
  3. antizyme expression requires programmed, ribosomal frameshifting
    Title: Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
  
enables ornithine decarboxylase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of polyamine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine decarboxylase antizyme 3
Names
ODC-Az 3
antizyme 3
testicular secretory protein Li 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134939.1 → NP_001128411.1  ornithine decarboxylase antizyme 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF175296, BC073949
    Consensus CDS
    CCDS58028.1
    UniProtKB/TrEMBL
    A0A0G2JH29
    Related
    ENSP00000313922.5, ENST00000321531.10
    Conserved Domains (2) summary
    pfam02100
    Location:87 → 178
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:67 → 94
    Cupredoxin; Cupredoxin superfamily

  2. NM_001301371.1 → NP_001288300.1  ornithine decarboxylase antizyme 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (3) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC073949, BI830988
    Consensus CDS
    CCDS76216.1
    UniProtKB/TrEMBL
    H0Y7Y4
    Related
    ENSP00000415904.2, ENST00000453029.2
    Conserved Domains (2) summary
    pfam02100
    Location:100 → 191
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:80 → 107
    Cupredoxin; Cupredoxin superfamily

  3. NM_016178.2 → NP_057262.2  ornithine decarboxylase antizyme 3 isoform 1

    See identical proteins and their annotated locations for NP_057262.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longest isoform (1).
    Source sequence(s)
    AF175296, BC073949
    Consensus CDS
    CCDS81378.1
    UniProtKB/Swiss-Prot
    E7EUE7, Q6GMR0, Q9UMX2
    UniProtKB/TrEMBL
    A8MW57
    Related
    ENSP00000383784.3, ENST00000400999.7
    Conserved Domains (2) summary
    pfam02100
    Location:132 → 223
    ODC_AZ; Ornithine decarboxylase antizyme
    cl19115
    Location:112 → 139
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151762969..151771330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150886358..150894807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UMX2.2 GenPept UniProtKB/Swiss-Prot:Q9UMX2

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