RASD1 ras related dexamethasone induced 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RASD1provided by HGNC
Official Full Name: ras related dexamethasone induced 1provided by HGNC
Primary source: HGNC:HGNC:15828
See related: Ensembl:ENSG00000108551 MIM:605550; AllianceGenome:HGNC:15828
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AGS1; DEXRAS1; MGC:26290
Summary: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]
Expression: Broad expression in fat (RPKM 57.3), kidney (RPKM 34.9) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (17494437..17496395, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (17441046..17443004, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (17397751..17399709, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia
Title: Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia.
Hsa-miR-375/RASD1 Signaling May Predict Local Control in Early Breast Cancer.
Title: Hsa-miR-375/RASD1 Signaling May Predict Local Control in Early Breast Cancer.
Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia.
Title: Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia.
High RASD1 expression is associated with B-cell acute lymphoblastic leukemia.
Title: High RASD1 transcript levels at diagnosis predicted poor survival in adult B-cell acute lymphoblastic leukemia patients.
Via a feedback loop involving miR-375, RASD1, and ERalpha.
Title: Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα.
These findings suggest that the upregulation of RASD1 in glioma tissues may play an inhibitory role in tumor expansion, possibly through inactivating the AKT/mTOR signaling pathway.
Title: Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway.
Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation.
Title: The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 protein Dexras1 (RASD1).
Title: PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation.
Loss of RASD1 is associated with prostate cancer.
Title: Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro.
Study showed that Rasd1 and NonO interact at the CRE-site of specific target genes.
Title: Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dexamethasone-induced Ras-related protein 1

Names: RAS, dexamethasone-induced 1; activator of G-protein signaling 1; ras-related protein

NP_001186918.1

EC 3.6.5.2

NP_057168.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028074.2 RefSeqGene

Range

5000..6958

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001199989.2 → NP_001186918.1 dexamethasone-induced Ras-related protein 1 isoform 2

See identical proteins and their annotated locations for NP_001186918.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate splice site in the CDS that results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC073621

Consensus CDS

CCDS58519.1

UniProtKB/Swiss-Prot

Q9Y272

Related

ENSP00000463388.1, ENST00000579152.1

Conserved Domains (1) summary

cl38936
Location:25 → 95

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_016084.5 → NP_057168.1 dexamethasone-induced Ras-related protein 1 isoform 1 proprotein

See identical proteins and their annotated locations for NP_057168.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC073621

Consensus CDS

CCDS11185.1

UniProtKB/Swiss-Prot

B2R709, B4DFF4, Q9NYB4, Q9Y272

Related

ENSP00000225688.3, ENST00000225688.4

Conserved Domains (1) summary

cd04143
Location:25 → 281

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)