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DHRS7 dehydrogenase/reductase 7 [ Homo sapiens (human) ]

Gene ID: 51635, updated on 3-Nov-2024

Summary

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Official Symbol
DHRS7provided by HGNC
Official Full Name
dehydrogenase/reductase 7provided by HGNC
Primary source
HGNC:HGNC:21524
See related
Ensembl:ENSG00000100612 MIM:612833; AllianceGenome:HGNC:21524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-86; SDR34C1; retDSR4; retSDR4
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
Expression
Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues See more
Orthologs
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Genomic context

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See DHRS7 in Genome Data Viewer
Location:
14q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60144119..60169889, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54350401..54376186, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60610837..60636607, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene leucine rich repeat containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene pecanex 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8470 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene 1 Neighboring gene ribosomal protein L17 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells. Rizzotto A, et al. Cells, 2023 Dec 27. PMID 38201261, Free PMC Article
  2. The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing. Zemanová L, et al. Int J Biol Macromol, 2017 Dec. PMID 28687384
  3. Human DHRS7, promising enzyme in metabolism of steroids and retinoids? Štambergová H, et al. J Steroid Biochem Mol Biol, 2016 Jan. PMID 26466768
  4. Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells. Skarka A, et al. Protein Expr Purif, 2014 Mar. PMID 24316191
  5. Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Stambergova H, et al. Chem Biol Interact, 2014 Jan 25. PMID 24246760

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells.
    Title: Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells.
  2. Single nucleotide polymorphism in DHRS7 gene is associated with smoking in African americans.
    Title: An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations.
  3. identification of new substrates of human DHRS7
    Title: The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing.
  4. Data suggest that (1) cortisone is a substrate of DHRS7 and is reduced to 20beta-dihydrocortisone, (2) androstenedione is not a relevant substrate of DHRS7, (3) DHRS7 catalyzes the oxidoreduction of 5alpha-dihydrotestosterone to 3alpha-androstanediol with a suppressive effect on androgen receptor transcriptional activity, and (4) DHRS7 is anchored in endoplasmic reticulum membrane with cytoplasmic orientation.
    Title: DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone?
  5. DHRS7 participates in the reductive metabolism of steroids and retinoids.Expression patterns of DHRS7 at the mRNA as well as protein level were determined in a panel of various human tissue samples.
    Title: Human DHRS7, promising enzyme in metabolism of steroids and retinoids?
  6. DHRS7 containing TEV-cleavable His10 and FLAG-tag was cloned and expressed in the Sf9 cell line.
    Title: Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells.
  7. DHRS7 is another enzyme from SDR superfamily that have been proved, at least in vitro, to contribute to the metabolism of xenobiotics with carbonyl group.
    Title: Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 7
Names
dehydrogenase/reductase (SDR family) member 7
retinal short-chain dehydrogenase/reductase 4
short chain dehydrogenase/reductase family 34C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322280.2 → NP_001309209.1  dehydrogenase/reductase SDR family member 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Consensus CDS
    CCDS81810.1
    UniProtKB/Swiss-Prot
    Q9Y394
    Related
    ENSP00000442993.2, ENST00000536410.6
    Conserved Domains (1) summary
    cd05332
    Location:2 → 258
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  2. NM_001322281.2 → NP_001309210.1  dehydrogenase/reductase SDR family member 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Conserved Domains (1) summary
    cl21454
    Location:1 → 168
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001322282.2 → NP_001309211.1  dehydrogenase/reductase SDR family member 7 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Conserved Domains (1) summary
    cl21454
    Location:48 → 228
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_016029.4 → NP_057113.1  dehydrogenase/reductase SDR family member 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057113.1

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Consensus CDS
    CCDS9743.1
    UniProtKB/Swiss-Prot
    B2R896, Q9UKU2, Q9Y394
    UniProtKB/TrEMBL
    Q659E8
    Related
    ENSP00000451882.1, ENST00000557185.6
    Conserved Domains (1) summary
    cd05332
    Location:48 → 308
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60144119..60169889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    54350401..54376186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y394.1 GenPept UniProtKB/Swiss-Prot:Q9Y394

Gene LinkOut

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Chemical Information
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