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LARP7 La ribonucleoprotein 7, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 51574, updated on 11-Apr-2024

Summary

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Official Symbol
LARP7provided by HGNC
Official Full Name
La ribonucleoprotein 7, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:24912
See related
Ensembl:ENSG00000174720 MIM:612026; AllianceGenome:HGNC:24912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALAZS; PIP7S; hLARP7; HDCMA18P
Summary
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4q25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112637143..112657586)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (115945482..115965926)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113558299..113578742)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene zinc finger GRF-type containing 1 Neighboring gene H3 histone pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113564861-113564962 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:113570027-113570749 Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 302a Neighboring gene microRNA 302c Neighboring gene microRNA 302b Neighboring gene microRNA 367 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113604501-113604662 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene GET1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood. Das S, et al. Am J Med Genet A, 2021 May. PMID 33569879
  2. Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism. Kazemi G, et al. Arch Iran Med, 2020 Dec 1. PMID 33356342
  3. Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome. Gana S, et al. Am J Med Genet A, 2020 Nov. PMID 32888391
  4. LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Sui X, et al. Mol Med Rep, 2018 Jun. PMID 29620212, Free PMC Article
  5. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. Holohan B, et al. BMC Genomics, 2016 Oct 17. PMID 27766953, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
    Title: LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
  2. Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
    Title: Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
  3. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
    Title: LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
  4. Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
    Title: Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
  5. Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.
    Title: Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.
  6. Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.
    Title: Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.
  7. Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.
    Title: Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.
  8. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
    Title: L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
  9. LARP7 functios as a bridging factor for snoRNA-guided modification of the U6 snRNA and alterations in splicing fidelity contribute to the etiology of the Alazami syndrome.
    Title: The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.
  10. LARP7 may have inhibited the proliferation and increased the radioiodine uptake of PTC cells by regulating the SHH signaling pathway.
    Title: LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephalic primordial dwarfism, Alazami type
MedGen: C3554439 OMIM: 615071 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC104360, DKFZp564K112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7SK snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in U6 2'-O-snRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in box C/D sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription elongation by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of viral transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of snRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of 7SK snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
la-related protein 7
Names
La ribonucleoprotein domain family member 7
P-TEFb-interaction protein for 7SK stability

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032779.1 RefSeqGene

    Range
    5180..25623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267039.4 → NP_001253968.2  la-related protein 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000422626.2, ENST00000509061.5
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454 → 535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

  2. NM_001370974.1 → NP_001357903.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93568.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467 → 565
    RRM_3; RNA binding motif

  3. NM_001370975.1 → NP_001357904.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93568.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Related
    ENSP00000511576.1, ENST00000694898.1
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467 → 565
    RRM_3; RNA binding motif

  4. NM_001370976.1 → NP_001357905.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93569.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, H0YA82
    Related
    ENSP00000426376.2, ENST00000511529.2
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:466 → 564
    RRM_3; RNA binding motif

  5. NM_001370977.1 → NP_001357906.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93569.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, H0YA82
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:466 → 564
    RRM_3; RNA binding motif

  6. NM_001370978.1 → NP_001357907.1  la-related protein 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000499190.1, ENST00000651579.1
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454 → 535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

  7. NM_001370979.1 → NP_001357908.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93570.1
    UniProtKB/TrEMBL
    A0A8Q3SHF1, A0A8Q3SHH4
    Related
    ENSP00000511571.1, ENST00000694891.1
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:453 → 551
    RRM_3; RNA binding motif

  8. NM_001370980.1 → NP_001357909.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93570.1
    UniProtKB/TrEMBL
    A0A8Q3SHF1, A0A8Q3SHH4
    Related
    ENSP00000511577.1, ENST00000694899.1
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:453 → 551
    RRM_3; RNA binding motif

  9. NM_001370981.1 → NP_001357910.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93571.1
    UniProtKB/TrEMBL
    A0A8I5KUI4, A0A8Q3SHF1
    Related
    ENSP00000508585.1, ENST00000693375.1
    Conserved Domains (4) summary
    COG0724
    Location:38 → 221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47 → 126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:375 → 473
    RRM_3; RNA binding motif
    cl02755
    Location:1 → 32
    LAM; LA motif RNA-binding domain

  10. NM_001370982.1 → NP_001357911.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93571.1
    UniProtKB/TrEMBL
    A0A8I5KUI4, A0A8Q3SHF1
    Related
    ENSP00000509527.1, ENST00000692416.1
    Conserved Domains (4) summary
    COG0724
    Location:38 → 221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47 → 126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:375 → 473
    RRM_3; RNA binding motif
    cl02755
    Location:1 → 32
    LAM; LA motif RNA-binding domain

  11. NM_015454.3 → NP_056269.1  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_056269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a 5' exon compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AL049996, BM979591, CA314598, CN346208
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000421541.2, ENST00000505034.6
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454 → 535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

  12. NM_016648.4 → NP_057732.2  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_057732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AC106864, AK000274, AL049996, DB270203
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000344950.5, ENST00000344442.10
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454 → 535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    112637143..112657586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415769.1 → XP_047271725.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHN7

  2. XM_047415771.1 → XP_047271727.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

  3. XM_024454083.2 → XP_024309851.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Conserved Domains (4) summary
    cd08032
    Location:30 → 111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117 → 300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126 → 205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467 → 565
    RRM_3; RNA binding motif

  4. XM_047415770.1 → XP_047271726.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

  5. XM_047415768.1 → XP_047271724.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHN7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    115945482..115965926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350164.1 → XP_054206139.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHN7

  2. XM_054350166.1 → XP_054206141.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

  3. XM_054350162.1 → XP_054206137.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHN7

  4. XM_054350165.1 → XP_054206140.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

  5. XM_054350163.1 → XP_054206138.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHN7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G0J3.1 GenPept UniProtKB/Swiss-Prot:Q4G0J3

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