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PEX5L peroxisomal biogenesis factor 5 like [ Homo sapiens (human) ]

Gene ID: 51555, updated on 3-Apr-2024

Summary

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Official Symbol
PEX5Lprovided by HGNC
Official Full Name
peroxisomal biogenesis factor 5 likeprovided by HGNC
Primary source
HGNC:HGNC:30024
See related
Ensembl:ENSG00000114757 MIM:611058; AllianceGenome:HGNC:30024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PXR2; PEX5R; PXR2B; PEX5RP; TRIP8b
Summary
Enables peroxisome matrix targeting signal-1 binding activity and small GTPase binding activity. Predicted to be involved in protein import into peroxisome matrix, docking and regulation of cAMP-mediated signaling. Predicted to act upstream of or within maintenance of protein location and regulation of membrane potential. Located in cytosol. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.5), testis (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
3q26.33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (179794958..180036937, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (182598483..182840049, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179512746..179754725, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179370658-179371301 Neighboring gene H3 histone pseudogene 13 Neighboring gene ubiquitin specific peptidase 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:179446047-179446626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:179446627-179447205 Neighboring gene uncharacterized LOC124909464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20872 Neighboring gene PEX5L antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20873 Neighboring gene uncharacterized LOC124909463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179732143-179732642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14925 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179791123-179791788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179796465-179796989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179819851-179820351 Neighboring gene uncharacterized LOC124909465 Neighboring gene NANOG hESC enhancer GRCh37_chr3:179852449-179852950 Neighboring gene RNA, 5S ribosomal pseudogene 149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Lyman KA, et al. J Biol Chem, 2017 Oct 27. PMID 28887304, Free PMC Article
  2. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival. Chen AS, et al. Mol Carcinog, 2022 Jul. PMID 35502931
  3. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. Bankston JR, et al. J Biol Chem, 2017 Oct 27. PMID 28864772, Free PMC Article
  4. Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. Han Y, et al. J Vis Exp, 2016 Nov 11. PMID 27911380, Free PMC Article
  5. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Saponaro A, et al. Proc Natl Acad Sci U S A, 2014 Oct 7. PMID 25197093, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.
    Title: Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.
  2. allosteric coupling of the TRIP8b TPR domains both promotes binding to HCN channels and limits binding to type 1 peroxisomal targeting signal substrates.
    Title: Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.
  3. TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels.
    Title: Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.
  4. the sequential formation of a highly stable trimeric complex involving cargo protein, PEX7 and PEX5L stabilizes cargo binding and is a prerequisite for PTS2-mediated peroxisomal import.
    Title: Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.
  5. Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
    Title: Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
  6. Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
    Title: Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
  7. TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression level and cyclic nucleotide dependence.
    Title: Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
  8. Seizure-dependent plasticity wound is not conditional upon TRIP8b in cerebral cortex.
    Title: TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
  9. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
    Title: Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of peroxisomal biogenesis factor 5-like (PEX5L; PXR2B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761J2017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peroxisome matrix targeting signal-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxisome targeting sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PEX5-related protein
Names
HCN channel auxiliary subunit
PEX2-related protein
PEX5-like protein
Pex5p-related protein
peroxin-5-related protein
peroxisome biogenesis factor 5-like
tetratricopeptide repeat-containing Rab8b-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256750.2 → NP_001243679.1  PEX5-related protein isoform 2

    See identical proteins and their annotated locations for NP_001243679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AB032592, AC007687, DA772743
    Consensus CDS
    CCDS58866.1
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000263962.8, ENST00000263962.12
    Conserved Domains (4) summary
    COG0457
    Location:264 → 537
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:472 → 500
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:509 → 539
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:508 → 569
    TPR_11; TPR repeat

  2. NM_001256751.2 → NP_001243680.1  PEX5-related protein isoform 3

    See identical proteins and their annotated locations for NP_001243680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AB032593, AC007687, AK299633, DA772743
    Consensus CDS
    CCDS58865.1
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000419348.1, ENST00000465751.5
    Conserved Domains (2) summary
    TIGR02917
    Location:307 → 537
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:450 → 478
    TPR; TPR repeat [structural motif]

  3. NM_001256752.2 → NP_001243681.1  PEX5-related protein isoform 4

    See identical proteins and their annotated locations for NP_001243681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform 4.
    Source sequence(s)
    AB032592, AC007687, BC036183, DA772743
    Consensus CDS
    CCDS58867.1
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000418440.1, ENST00000485199.5
    Conserved Domains (2) summary
    TIGR02917
    Location:296 → 526
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:439 → 467
    TPR; TPR repeat [structural motif]

  4. NM_001256753.2 → NP_001243682.1  PEX5-related protein isoform 5

    See identical proteins and their annotated locations for NP_001243682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform 5.
    Source sequence(s)
    AB032593, AC007687, AK294501, DA772743
    Consensus CDS
    CCDS58864.1
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000418054.1, ENST00000472994.5
    Conserved Domains (2) summary
    TIGR02917
    Location:272 → 502
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:415 → 443
    TPR; TPR repeat [structural motif]

  5. NM_001256754.2 → NP_001243683.1  PEX5-related protein isoform 6

    See identical proteins and their annotated locations for NP_001243683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 18, encodes isoform 6.
    Source sequence(s)
    AC007687, AC092939, AK295386, AK303716
    Consensus CDS
    CCDS58863.1
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000420555.1, ENST00000476138.5
    Conserved Domains (2) summary
    TIGR02917
    Location:288 → 518
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:431 → 459
    TPR; TPR repeat [structural motif]

  6. NM_001256755.2 → NP_001243684.1  PEX5-related protein isoform 7

    See identical proteins and their annotated locations for NP_001243684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC007687, AC092939, AK295349, AK295386, AK303716
    Consensus CDS
    CCDS58862.1
    UniProtKB/TrEMBL
    B7Z219
    Related
    ENSP00000417270.1, ENST00000464614.5
    Conserved Domains (2) summary
    sd00006
    Location:366 → 394
    TPR; TPR repeat [structural motif]
    cl26002
    Location:223 → 453
    TPR_11; TPR repeat

  7. NM_001256756.2 → NP_001243685.1  PEX5-related protein isoform 8

    See identical proteins and their annotated locations for NP_001243685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 22-28, encodes isoform 8.
    Source sequence(s)
    AB032593, AC007687, AC092939, AK295386
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Related
    ENSP00000418665.1, ENST00000468741.5
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  8. NM_001349386.2 → NP_001336315.1  PEX5-related protein isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (9).
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:529 → 557
    TPR; TPR repeat [structural motif]
    cl26002
    Location:386 → 616
    TPR_11; TPR repeat

  9. NM_001349387.2 → NP_001336316.1  PEX5-related protein isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 10.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:498 → 526
    TPR; TPR repeat [structural motif]
    cl26002
    Location:355 → 585
    TPR_11; TPR repeat

  10. NM_001349388.2 → NP_001336317.1  PEX5-related protein isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 10.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:498 → 526
    TPR; TPR repeat [structural motif]
    cl26002
    Location:355 → 585
    TPR_11; TPR repeat

  11. NM_001349389.2 → NP_001336318.1  PEX5-related protein isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform 11.
    Source sequence(s)
    AC007687, AC090024, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:496 → 524
    TPR; TPR repeat [structural motif]
    cl26002
    Location:353 → 583
    TPR_11; TPR repeat

  12. NM_001349390.2 → NP_001336319.1  PEX5-related protein isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform 12.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:494 → 522
    TPR; TPR repeat [structural motif]
    cl26002
    Location:351 → 581
    TPR_11; TPR repeat

  13. NM_001349391.2 → NP_001336320.1  PEX5-related protein isoform 13

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform 13.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:464 → 492
    TPR; TPR repeat [structural motif]
    cl26002
    Location:321 → 551
    TPR_11; TPR repeat

  14. NM_001349392.2 → NP_001336321.1  PEX5-related protein isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 14.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:463 → 491
    TPR; TPR repeat [structural motif]
    cl26002
    Location:320 → 550
    TPR_11; TPR repeat

  15. NM_001349393.2 → NP_001336322.1  PEX5-related protein isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 14.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:463 → 491
    TPR; TPR repeat [structural motif]
    cl26002
    Location:320 → 550
    TPR_11; TPR repeat

  16. NM_001349394.2 → NP_001336323.1  PEX5-related protein isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform 15.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:433 → 461
    TPR; TPR repeat [structural motif]
    cl26002
    Location:290 → 520
    TPR_11; TPR repeat

  17. NM_001349395.2 → NP_001336324.1  PEX5-related protein isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58863.1
    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    TIGR02917
    Location:288 → 518
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:431 → 459
    TPR; TPR repeat [structural motif]

  18. NM_001349396.2 → NP_001336325.1  PEX5-related protein isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform 16.
    Source sequence(s)
    AC007687, AC090024, AC092939
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    sd00006
    Location:407 → 435
    TPR; TPR repeat [structural motif]
    cl26002
    Location:264 → 494
    TPR_11; TPR repeat

  19. NM_001349397.2 → NP_001336326.1  PEX5-related protein isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes isoform 17.
    Source sequence(s)
    AC007687, AC092939
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    sd00006
    Location:398 → 426
    TPR; TPR repeat [structural motif]
    cl26002
    Location:255 → 485
    TPR_11; TPR repeat

  20. NM_001349398.2 → NP_001336327.1  PEX5-related protein isoform 18

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes isoform 18.
    Source sequence(s)
    AC007687, AC090024, AC092939
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    sd00006
    Location:385 → 413
    TPR; TPR repeat [structural motif]
    cl26002
    Location:242 → 472
    TPR_11; TPR repeat

  21. NM_001349399.2 → NP_001336328.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 8 and 23-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  22. NM_001349401.2 → NP_001336330.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 8, 22, and 24-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  23. NM_001349404.2 → NP_001336333.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variants 8, 22, 23, and 25-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  24. NM_001349406.2 → NP_001336335.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variants 8, 22-24, and 26-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  25. NM_001349408.2 → NP_001336337.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variants 8, 22-25, 27, and 28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  26. NM_001349409.2 → NP_001336338.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variants 8, 22-26, and 28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  27. NM_001349410.2 → NP_001336339.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variants 8 and 22-27, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  28. NM_016559.3 → NP_057643.1  PEX5-related protein isoform 1

    See identical proteins and their annotated locations for NP_057643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB032593, AC007687, DA772743
    Consensus CDS
    CCDS3236.1
    UniProtKB/Swiss-Prot
    B7Z2A5, B7Z305, B7Z318, B7Z5Z5, B7Z8P2, E7EUV8, E7EUZ0, E9PEC1, E9PH97, Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4
    UniProtKB/TrEMBL
    B2RAP5
    Related
    ENSP00000419975.1, ENST00000467460.6
    Conserved Domains (2) summary
    TIGR02917
    Location:331 → 561
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:474 → 502
    TPR; TPR repeat [structural motif]

RNA

  1. NR_146167.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007687, AC092939

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    179794958..180036937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448299.1 → XP_047304255.1  PEX5-related protein isoform X8

  2. XM_047448298.1 → XP_047304254.1  PEX5-related protein isoform X7

  3. XM_047448297.1 → XP_047304253.1  PEX5-related protein isoform X6

  4. XM_024453591.2 → XP_024309359.1  PEX5-related protein isoform X2

    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    TIGR02917
    Location:377 → 607
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:520 → 548
    TPR; TPR repeat [structural motif]

  5. XM_024453593.2 → XP_024309361.1  PEX5-related protein isoform X5

    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    sd00006
    Location:429 → 457
    TPR; TPR repeat [structural motif]
    cl26002
    Location:286 → 516
    TPR_11; TPR repeat

  6. XM_024453592.2 → XP_024309360.1  PEX5-related protein isoform X3

    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:486 → 514
    TPR; TPR repeat [structural motif]
    cl26002
    Location:343 → 573
    TPR_11; TPR repeat

  7. XM_024453590.2 → XP_024309358.1  PEX5-related protein isoform X1

    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (2) summary
    sd00006
    Location:551 → 579
    TPR; TPR repeat [structural motif]
    cl26002
    Location:408 → 638
    TPR_11; TPR repeat

  8. XM_011512891.3 → XP_011511193.1  PEX5-related protein isoform X9

    See identical proteins and their annotated locations for XP_011511193.1

    UniProtKB/TrEMBL
    B7Z219
    Conserved Domains (2) summary
    TIGR02917
    Location:139 → 369
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:282 → 310
    TPR; TPR repeat [structural motif]

  9. XM_011512888.3 → XP_011511190.1  PEX5-related protein isoform X4

    UniProtKB/TrEMBL
    B2RAP5
    Conserved Domains (4) summary
    COG0457
    Location:236 → 509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:444 → 472
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:481 → 511
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:480 → 541
    TPR_11; TPR repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    182598483..182840049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346825.1 → XP_054202800.1  PEX5-related protein isoform X8

  2. XM_054346824.1 → XP_054202799.1  PEX5-related protein isoform X7

  3. XM_054346823.1 → XP_054202798.1  PEX5-related protein isoform X6

  4. XM_054346819.1 → XP_054202794.1  PEX5-related protein isoform X2

  5. XM_054346822.1 → XP_054202797.1  PEX5-related protein isoform X5

  6. XM_054346820.1 → XP_054202795.1  PEX5-related protein isoform X3

  7. XM_054346818.1 → XP_054202793.1  PEX5-related protein isoform X1

  8. XM_054346826.1 → XP_054202801.1  PEX5-related protein isoform X9

  9. XM_054346821.1 → XP_054202796.1  PEX5-related protein isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYB4.2 GenPept UniProtKB/Swiss-Prot:Q8IYB4

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