U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TRMO tRNA methyltransferase O [ Homo sapiens (human) ]

Gene ID: 51531, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TRMOprovided by HGNC
Official Full Name
tRNA methyltransferase Oprovided by HGNC
Primary source
HGNC:HGNC:30967
See related
Ensembl:ENSG00000136932 AllianceGenome:HGNC:30967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; HSPC219; C9orf156
Summary
Enables tRNA (adenine-N6-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9q22.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97896855..97922500, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110061668..110094437, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100659137..100684782, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100465986-100467185 Neighboring gene keratin 18 pseudogene 13 Neighboring gene papillary thyroid carcinoma susceptibility candidate 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100520047-100521246 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534165-100534666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534667-100535166 Neighboring gene VISTA enhancer hs1595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20103 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100571176-100572375 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:100589760-100589981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100613975-100614476 Neighboring gene VISTA enhancer hs1596 Neighboring gene VISTA enhancers hs1597 and hs1717 Neighboring gene forkhead box E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28679 Neighboring gene hemogen Neighboring gene Sharpr-MPRA regulatory region 4249 Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594 Neighboring gene uncharacterized LOC124902226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100745493-100746375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20110 Neighboring gene uncharacterized LOC124902225 Neighboring gene acidic nuclear phosphoprotein 32 family member B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. Liu LX, et al. J Biol Chem, 1997 May 23. PMID 9153233
  2. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Moreno LM, et al. Hum Mol Genet, 2009 Dec 15. PMID 19779022, Free PMC Article
  3. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. Takahashi M, et al. Hum Mol Genet, 2010 Jun 15. PMID 20350937
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
  5. Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. Kimura S, et al. Nucleic Acids Res, 2014 Aug. PMID 25063302, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
Nef (lentivirus myristoylated factor) associated protein 1
Nef associated protein 1
nef-associated protein 1
thioesterase NAP1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330725.2 → NP_001317654.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  2. NM_001371657.1 → NP_001358586.1  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q5T113, Q86SK0, Q9BU70, Q9NXJ7, Q9P0Q7
    Conserved Domains (2) summary
    pfam18389
    Location:335 → 403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

  3. NM_001371658.1 → NP_001358587.1  tRNA (adenine(37)-N6)-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (1) summary
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

  4. NM_001371659.1 → NP_001358588.1  tRNA (adenine(37)-N6)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:261 → 329
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:2 → 90
    UPF0066; Uncharacterized protein family UPF0066

  5. NM_001371660.1 → NP_001358589.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  6. NM_001371661.1 → NP_001358590.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Related
    ENSP00000364259.1, ENST00000375118.1
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  7. NM_016481.5 → NP_057565.3  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_057565.3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q5T113, Q86SK0, Q9BU70, Q9NXJ7, Q9P0Q7
    Related
    ENSP00000364260.3, ENST00000375119.8
    Conserved Domains (2) summary
    pfam18389
    Location:335 → 403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    97896855..97922500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518776.4 → XP_011517078.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    Conserved Domains (1) summary
    cd09281
    Location:32 → 159
    UPF0066; Escherichia coli YaeB and related proteins

  2. XM_047423465.1 → XP_047279421.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110061668..110094437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363085.1 → XP_054219060.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

  2. XM_054363086.1 → XP_054219061.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BU70.2 GenPept UniProtKB/Swiss-Prot:Q9BU70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous