U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ANAPC5 anaphase promoting complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 51433, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ANAPC5provided by HGNC
Official Full Name
anaphase promoting complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:15713
See related
Ensembl:ENSG00000089053 MIM:606948; AllianceGenome:HGNC:15713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC5
Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in lymph node (RPKM 32.0), bone marrow (RPKM 28.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12q24.31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121308245..121354209, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121299648..121345630, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121746048..121792012, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121661200-121661700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7159 Neighboring gene Sharpr-MPRA regulatory region 10951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121671545-121672172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4971 Neighboring gene purinergic receptor P2X 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121683587-121683800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121693396-121693896 Neighboring gene calcium/calmodulin dependent protein kinase kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720271-121720878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720879-121721486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4972 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7164 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:121838029-121838560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121838561-121839092 Neighboring gene MPRA-validated peak2014 silencer Neighboring gene ring finger protein 34 Neighboring gene lysine demethylase 2B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. Autieri MV. Biochem Biophys Res Commun, 2001 Apr 6. PMID 11401522
  2. Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway. Xu M, et al. Mol Med Rep, 2017 Oct. PMID 28731177, Free PMC Article
  3. Cross-talk between APC/C and CBP/p300. Liu J, et al. Cancer Biol Ther, 2006 Jul. PMID 16861917
  4. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Budhavarapu VN, et al. Cell Cycle, 2012 May 15. PMID 22580462, Free PMC Article
  5. The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. Koloteva-Levine N, et al. Mol Cell Biol, 2004 May. PMID 15082755, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth.
    Title: Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway.
  2. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
    Title: Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
  3. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
    Title: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
  4. APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
    Title: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
  5. Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
    Title: The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
anaphase-promoting complex subunit 5
Names
cyclosome subunit 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137559.1 → NP_001131031.1  anaphase-promoting complex subunit 5 isoform b

    See identical proteins and their annotated locations for NP_001131031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the internal coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AA349724, AK025614, BX381618
    Consensus CDS
    CCDS45000.1
    UniProtKB/Swiss-Prot
    Q9UJX4
    Related
    ENSP00000415061.2, ENST00000441917.6
    Conserved Domains (3) summary
    sd00016
    Location:149 → 183
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:1 → 66
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:155 → 255
    ANAPC5; Anaphase-promoting complex subunit 5

  2. NM_001330489.2 → NP_001317418.1  anaphase-promoting complex subunit 5 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) is shorter but has the same N- and C-termini as isoform a.
    Source sequence(s)
    AA349724, AI879332, BC001950, BX381618, CR980654
    Consensus CDS
    CCDS81749.1
    UniProtKB/TrEMBL
    F5H0F9
    Related
    ENSP00000439875.1, ENST00000541887.5
    Conserved Domains (5) summary
    sd00016
    Location:248 → 282
    Apc5; TPR repeat [structural motif]
    sd00006
    Location:454 → 482
    TPR; TPR repeat [structural motif]
    cd16270
    Location:32 → 165
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:254 → 354
    ANAPC5; Anaphase-promoting complex subunit 5
    pfam17874
    Location:439 → 685
    TPR_MalT; MalT-like TPR region

  3. NM_016237.5 → NP_057321.2  anaphase-promoting complex subunit 5 isoform a

    See identical proteins and their annotated locations for NP_057321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA349724, AI879332, BC001950, BX381618
    Consensus CDS
    CCDS9220.1
    UniProtKB/Swiss-Prot
    E9PFB2, Q8N4H7, Q9BQD4, Q9UJX4
    Related
    ENSP00000261819.3, ENST00000261819.8
    Conserved Domains (5) summary
    sd00016
    Location:248 → 282
    Apc5; TPR repeat [structural motif]
    sd00006
    Location:467 → 495
    TPR; TPR repeat [structural motif]
    cd16270
    Location:32 → 165
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:254 → 354
    ANAPC5; Anaphase-promoting complex subunit 5
    pfam17874
    Location:452 → 698
    TPR_MalT; MalT-like TPR region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121308245..121354209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121299648..121345630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJX4.2 GenPept UniProtKB/Swiss-Prot:Q9UJX4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous