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UCHL5 ubiquitin C-terminal hydrolase L5 [ Homo sapiens (human) ]

Gene ID: 51377, updated on 7-Apr-2024

Summary

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Official Symbol
UCHL5provided by HGNC
Official Full Name
ubiquitin C-terminal hydrolase L5provided by HGNC
Primary source
HGNC:HGNC:19678
See related
Ensembl:ENSG00000116750 MIM:610667; AllianceGenome:HGNC:19678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCH37; CGI-70; INO80R; UCH-L5
Summary
Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1q31.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (193012254..193060076, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (192359462..192407284, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192981384..193029206, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RSG2 antisense RNA 1 Neighboring gene zinc finger protein 101 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:192979786-192979951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2265 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028176-193028908 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028909-193029641 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene Ro60, Y RNA binding protein Neighboring gene Sharpr-MPRA regulatory region 7925 Neighboring gene uncharacterized LOC124904474 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193082253-193083159 Neighboring gene Sharpr-MPRA regulatory region 4625 Neighboring gene glutaredoxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation. Deol KK, et al. Mol Cell, 2020 Dec 3. PMID 33156996, Free PMC Article
  2. Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis. Arpalahti L, et al. PLoS One, 2018. PMID 29474458, Free PMC Article
  3. UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Arpalahti L, et al. Tumour Biol, 2017 Jul. PMID 28681694
  4. Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma. Arpalahti L, et al. Tumour Biol, 2017 Jun. PMID 28653876
  5. High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer. Wang L, et al. Tumour Biol, 2014 Nov. PMID 25123264

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The TGF-beta/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.
    Title: The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.
  2. MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
    Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
  3. Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
    Title: Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
  4. A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.
    Title: A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.
  5. UCHL5 controls beta-catenin destruction complex function through Axin1 regulation.
    Title: UCHL5 controls β-catenin destruction complex function through Axin1 regulation.
  6. Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.
    Title: Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.
  7. Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
    Title: Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
  8. LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
    Title: LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
  9. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
    Title: Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
  10. Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
    Title: Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of DSM-IV cannabis dependence.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in forebrain morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in lateral ventricle development IEA
Inferred from Electronic Annotation
more info
  
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic proteasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L5
Names
INO80 complex subunit R
ubiquitin C-terminal hydrolase UCH37
ubiquitin carboxyl-terminal esterase L5
ubiquitin carboxyl-terminal hydrolase L5
ubiquitin thioesterase L5
NP_001186190.1
NP_001186191.1
NP_001186192.1
NP_001337769.1
NP_001337770.1
NP_001337771.1
NP_001337772.1
NP_001337773.1
NP_001337774.1
NP_001337775.1
NP_001337776.1
NP_001337777.1
NP_001337778.1
NP_001337779.1
NP_001337780.1
NP_001337781.1
NP_057068.1
XP_006711430.2
XP_006711432.2
XP_006711433.3
XP_006711434.1
XP_011507906.2
XP_011507909.1
XP_016856922.2
XP_016856927.1
XP_047278266.1
XP_047278278.1
XP_047278280.1
XP_047278285.1
XP_047278289.1
XP_047278300.1
XP_047278309.1
XP_047278316.1
XP_047278319.1
XP_047278322.1
XP_047278327.1
XP_047278328.1
XP_054192913.1
XP_054192914.1
XP_054192915.1
XP_054192916.1
XP_054192917.1
XP_054192918.1
XP_054192919.1
XP_054192920.1
XP_054192921.1
XP_054192922.1
XP_054192923.1
XP_054192924.1
XP_054192925.1
XP_054192926.1
XP_054192927.1
XP_054192928.1
XP_054192929.1
XP_054192930.1
XP_054192931.1
XP_054192932.1
XP_054192933.1
XP_054192934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199261.3 → NP_001186190.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

    See identical proteins and their annotated locations for NP_001186190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AL136370, BC015521, BP397519, DA255130
    Consensus CDS
    CCDS55668.1
    UniProtKB/TrEMBL
    B2RB07
    Related
    ENSP00000356424.1, ENST00000367454.6
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:263 → 308
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  2. NM_001199262.3 → NP_001186191.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3

    See identical proteins and their annotated locations for NP_001186191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL136370, BC025369, DN916480
    Consensus CDS
    CCDS55670.1
    UniProtKB/TrEMBL
    B2RB07
    Related
    ENSP00000356418.1, ENST00000367448.5
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:263 → 308
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  3. NM_001199263.3 → NP_001186192.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4

    See identical proteins and their annotated locations for NP_001186192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF151828, AL136370, BC025369, DA255130, DN916480
    Consensus CDS
    CCDS55669.1
    UniProtKB/TrEMBL
    B2RB07
    Related
    ENSP00000356419.1, ENST00000367449.5
    Conserved Domains (1) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  4. NM_001350840.2 → NP_001337769.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BP397519, DR760216
    UniProtKB/TrEMBL
    Q5LJA9
    Conserved Domains (1) summary
    cd02255
    Location:46 → 270
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  5. NM_001350841.2 → NP_001337770.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BP397519, DA255130, DB172473, DR760216
    UniProtKB/TrEMBL
    Q5LJA9
    Related
    ENSP00000356420.3, ENST00000367450.7
    Conserved Domains (2) summary
    cd02255
    Location:8 → 250
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:291 → 336
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  6. NM_001350842.2 → NP_001337771.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BP397519, DA255130, DR760216
    Consensus CDS
    CCDS86041.1
    UniProtKB/TrEMBL
    Q5LJA5, Q5LJA9
    Related
    ENSP00000356421.4, ENST00000367451.8
    Conserved Domains (2) summary
    cd02255
    Location:8 → 250
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:290 → 335
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  7. NM_001350843.2 → NP_001337772.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BC025369, BP397519, DR760216
    UniProtKB/TrEMBL
    Q5LJA9
    Conserved Domains (2) summary
    cd02255
    Location:8 → 250
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:290 → 335
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  8. NM_001350844.2 → NP_001337773.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BP397519
    UniProtKB/TrEMBL
    B2RB07
    Conserved Domains (1) summary
    cd02255
    Location:46 → 243
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  9. NM_001350845.2 → NP_001337774.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF151828, AL136370, BC015521, BC025369, DA255130, DB172473, DN916480, DR760216
    UniProtKB/TrEMBL
    Q5LJA9
    Conserved Domains (1) summary
    cd02255
    Location:8 → 250
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  10. NM_001350846.2 → NP_001337775.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL136370, BM701303, BP397519, CX758593
    UniProtKB/TrEMBL
    B2RB07
    Conserved Domains (1) summary
    cd02255
    Location:12 → 214
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  11. NM_001350847.2 → NP_001337776.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL136370, BP397519, CX758593, DA316048
    UniProtKB/TrEMBL
    B2RB07
    Conserved Domains (1) summary
    cd02255
    Location:12 → 214
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  12. NM_001350848.2 → NP_001337777.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AF147717, AL136370, BP397519, DC295313, DC420886
    UniProtKB/TrEMBL
    B7Z9U9
    Conserved Domains (2) summary
    cd02255
    Location:1 → 99
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:140 → 185
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  13. NM_001350849.2 → NP_001337778.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AF147717, AL136370, BP397519, DA255130, DR422870
    UniProtKB/TrEMBL
    B7Z9U9
    Related
    ENSP00000408720.1, ENST00000420791.5
    Conserved Domains (2) summary
    cd02255
    Location:1 → 99
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:140 → 185
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  14. NM_001350850.2 → NP_001337779.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AF147717, AL136370, BP397519, CB155982, DC295313, DC420886
    UniProtKB/TrEMBL
    B7Z9U9
    Conserved Domains (2) summary
    cd02255
    Location:1 → 99
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:139 → 184
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  15. NM_001350851.2 → NP_001337780.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AF147717, AL136370, BP397519, CB155982, HY081343
    UniProtKB/TrEMBL
    B7Z9U9
    Conserved Domains (2) summary
    cd02255
    Location:1 → 99
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:139 → 184
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  16. NM_001350852.2 → NP_001337781.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AF147717, AL136370, BC025369, BX111590, DC295313, DC420886, DN916480
    UniProtKB/TrEMBL
    B7Z9U9
    Related
    ENSP00000391153.1, ENST00000443327.5
    Conserved Domains (2) summary
    cd02255
    Location:1 → 99
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:139 → 184
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  17. NM_015984.5 → NP_057068.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

    See identical proteins and their annotated locations for NP_057068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF147717, AL136370, BP397519, DA255130
    Consensus CDS
    CCDS1378.1
    UniProtKB/Swiss-Prot
    Q5LJA6, Q5LJA7, Q8TBS4, Q96BJ9, Q9H1W5, Q9P0I3, Q9UQN2, Q9Y5K5
    UniProtKB/TrEMBL
    B2RB07
    Related
    ENSP00000356425.3, ENST00000367455.8
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:264 → 309
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

RNA

  1. NR_037607.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon and differs at an internal splice site and at the 3' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK301381, BI548319

  2. NR_146930.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC015521, BC025369, BP397519, BX484791, DR760216

  3. NR_146931.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136370, BC025369, BX484791, DB172473, DN916480, DR760216

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    193012254..193060076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422329.1 → XP_047278285.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X7

  2. XM_006711370.5 → XP_006711433.3  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X6

    UniProtKB/TrEMBL
    Q5LJA9

  3. XM_017001438.2 → XP_016856927.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

    UniProtKB/TrEMBL
    B7Z9U9
    Conserved Domains (2) summary
    cd02255
    Location:1 → 126
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:167 → 212
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  4. XM_047422333.1 → XP_047278289.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X9

  5. XM_011509607.3 → XP_011507909.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X8

    See identical proteins and their annotated locations for XP_011507909.1

    UniProtKB/TrEMBL
    Q5LJA9
    Conserved Domains (1) summary
    cd02255
    Location:12 → 241
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

  6. XM_006711371.4 → XP_006711434.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

    UniProtKB/TrEMBL
    B7Z9U9
    Conserved Domains (2) summary
    cd02255
    Location:1 → 126
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:167 → 212
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  7. XM_006711367.5 → XP_006711430.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  8. XM_047422360.1 → XP_047278316.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X12

  9. XM_047422366.1 → XP_047278322.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X14

  10. XM_047422371.1 → XP_047278327.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X15

  11. XM_047422353.1 → XP_047278309.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X11

  12. XM_047422363.1 → XP_047278319.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X13

    Related
    ENSP00000389563.1, ENST00000421683.1

  13. XM_047422344.1 → XP_047278300.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X10

  14. XM_017001433.3 → XP_016856922.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X3

  15. XM_006711369.4 → XP_006711432.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

  16. XM_011509604.3 → XP_011507906.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  17. XM_047422372.1 → XP_047278328.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X16

  18. XM_047422310.1 → XP_047278266.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  19. XM_047422324.1 → XP_047278280.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X5

  20. XM_047422322.1 → XP_047278278.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    192359462..192407284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336948.1 → XP_054192923.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X7

  2. XM_054336947.1 → XP_054192922.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X6

  3. XM_054336958.1 → XP_054192933.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

  4. XM_054336950.1 → XP_054192925.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X9

  5. XM_054336949.1 → XP_054192924.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X8

  6. XM_054336959.1 → XP_054192934.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

  7. XM_054336939.1 → XP_054192914.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  8. XM_054336953.1 → XP_054192928.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X12

  9. XM_054336955.1 → XP_054192930.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X14

  10. XM_054336956.1 → XP_054192931.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X15

  11. XM_054336952.1 → XP_054192927.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X11

  12. XM_054336954.1 → XP_054192929.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X13

  13. XM_054336951.1 → XP_054192926.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X10

  14. XM_054336944.1 → XP_054192919.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X3

  15. XM_054336943.1 → XP_054192918.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X19

  16. XM_054336942.1 → XP_054192917.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

  17. XM_054336941.1 → XP_054192916.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X18

  18. XM_054336938.1 → XP_054192913.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  19. XM_054336957.1 → XP_054192932.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X16

  20. XM_054336940.1 → XP_054192915.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

  21. XM_054336946.1 → XP_054192921.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X5

  22. XM_054336945.1 → XP_054192920.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5K5.3 GenPept UniProtKB/Swiss-Prot:Q9Y5K5

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