CFI complement factor I [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CFIprovided by VGNC
Official Full Name: complement factor Iprovided by VGNC
Primary source: VGNC:VGNC:27252
See related: BGD:BT13407; Ensembl:ENSBTAG00000034501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: IF
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (15614421..15664738)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: complement factor I

Names: I factor (complement); complement component 1

NP_001033185.1

EC 3.4.21.45

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038096.1 → NP_001033185.1 complement factor I precursor

See identical proteins and their annotated locations for NP_001033185.1

Status: PROVISIONAL

Source sequence(s)

BC108104

UniProtKB/TrEMBL

F1N4M7, Q32PI4

Related

ENSBTAP00000068946.2, ENSBTAT00000069487.2

Conserved Domains (7) summary

smart00020
Location:375 → 604

Tryp_SPc; Trypsin-like serine protease

smart00057
Location:82 → 146

FIMAC; factor I membrane attack complex

smart00202
Location:153 → 250

SR; Scavenger receptor Cys-rich

cd00112
Location:260 → 291

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:376 → 607

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:292 → 328

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00530
Location:179 → 249

SRCR; Scavenger receptor cysteine-rich domain