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PLAC8 placenta associated 8 [ Homo sapiens (human) ]

Gene ID: 51316, updated on 5-Mar-2024

Summary

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Official Symbol
PLAC8provided by HGNC
Official Full Name
placenta associated 8provided by HGNC
Primary source
HGNC:HGNC:19254
See related
Ensembl:ENSG00000145287 MIM:607515; AllianceGenome:HGNC:19254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15; DGIC; onzin; PNAS-144
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 48.1), colon (RPKM 47.5) and 10 other tissues See more
Orthologs
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Genomic context

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See PLAC8 in Genome Data Viewer
Location:
4q21.22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (83090048..83114729, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86419237..86443896, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84011201..84035882, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15537 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83933797-83934682 Neighboring gene RNA, U6 small nuclear 615, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21671 Neighboring gene Sharpr-MPRA regulatory region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83956719-83957224 Neighboring gene COP9 signalosome subunit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21678 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:84042619-84042813 Neighboring gene uncharacterized LOC124900167 Neighboring gene Sharpr-MPRA regulatory region 10366 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:84091705-84092904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:84102258-84102833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:84115858-84116088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21685 Neighboring gene aminomethyltransferase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. Ugalde AP, et al. EMBO J, 2022 Nov 2. PMID 36124427, Free PMC Article
  2. PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β-Catenin Signaling. Chen W, et al. J Immunol Res, 2022. PMID 35497881, Free PMC Article
  3. Placenta-specific 8 (PLAC8) mediates inflammation and mobility of the hPDLCs via MEK/ERK signaling pathway. Zhao C, et al. Int Immunopharmacol, 2022 Feb. PMID 34954560
  4. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer. Chen Y, et al. J Cell Mol Med, 2021 Jul. PMID 34117724, Free PMC Article
  5. PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells. Feng X, et al. FASEB J, 2021 Mar. PMID 33570788

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.
    Title: Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.
  2. PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway.
    Title: PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway.
  3. Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
    Title: Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
  4. Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
    Title: Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
  5. PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/beta-Catenin Signaling.
    Title: PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β-Catenin Signaling.
  6. Placenta-specific 8 (PLAC8) mediates inflammation and mobility of the hPDLCs via MEK/ERK signaling pathway.
    Title: Placenta-specific 8 (PLAC8) mediates inflammation and mobility of the hPDLCs via MEK/ERK signaling pathway.
  7. Long noncoding RNA HOXD-AS1 promotes the progression of pancreatic cancer through miR-664b-3p/PLAC8 axis.
    Title: Long noncoding RNA HOXD-AS1 promotes the progression of pancreatic cancer through miR-664b-3p/PLAC8 axis.
  8. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer.
    Title: PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer.
  9. PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells.
    Title: PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells.
  10. Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
    Title: Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
placenta-specific gene 8 protein
Names
down-regulated in gastrointestinal cancer protein
placenta specific 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130715.2 → NP_001124187.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_001124187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1.
    Source sequence(s)
    AC073840, AK000140
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    C1K3N2, Q9NZF1
    UniProtKB/TrEMBL
    A0A024RDH7, Q96EJ4, X2BQ60
    Related
    ENSP00000399700.2, ENST00000426923.2
    Conserved Domains (1) summary
    cl04722
    Location:24 → 108
    PLAC8; PLAC8 family

  2. NM_001130716.2 → NP_001124188.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_001124188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC073840, BI824905
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    C1K3N2, Q9NZF1
    UniProtKB/TrEMBL
    A0A024RDH7, Q96EJ4, X2BQ60
    Related
    ENSP00000412230.2, ENST00000411416.6
    Conserved Domains (1) summary
    cl04722
    Location:24 → 108
    PLAC8; PLAC8 family

  3. NM_016619.3 → NP_057703.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_057703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC073840, AK000140
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    C1K3N2, Q9NZF1
    UniProtKB/TrEMBL
    A0A024RDH7, Q96EJ4, X2BQ60
    Related
    ENSP00000309509.4, ENST00000311507.9
    Conserved Domains (1) summary
    cl04722
    Location:24 → 108
    PLAC8; PLAC8 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    83090048..83114729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    86419237..86443896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZF1.1 GenPept UniProtKB/Swiss-Prot:Q9NZF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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