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FKBP11 FKBP prolyl isomerase 11 [ Homo sapiens (human) ]

Gene ID: 51303, updated on 5-Mar-2024

Summary

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Official Symbol
FKBP11provided by HGNC
Official Full Name
FKBP prolyl isomerase 11provided by HGNC
Primary source
HGNC:HGNC:18624
See related
Ensembl:ENSG00000134285 MIM:610571; AllianceGenome:HGNC:18624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP19
Summary
FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues See more
Orthologs
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Genomic context

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See FKBP11 in Genome Data Viewer
Location:
12q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48921963..48939034, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48884157..48887686, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49315746..49319275, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4414 Neighboring gene ribosomal protein L32 pseudogene 27 Neighboring gene coiled-coil domain containing 65 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4415 Neighboring gene ADP ribosylation factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49338542-49339042 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49340991-49341204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49341223-49341815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49349467-49350462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6297 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49353706-49353915 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49358123-49358716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49360112-49360664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49361393-49362276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4416 Neighboring gene Sharpr-MPRA regulatory region 4091 Neighboring gene Wnt family member 10B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma. Thokerunga E, et al. Cancer Biomark, 2023. PMID 37248890
  2. FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma. Zeng D, et al. Aging (Albany NY), 2023 Apr 1. PMID 37014329, Free PMC Article
  3. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Preisendörfer S, et al. Cells, 2022 Apr 14. PMID 35456020, Free PMC Article
  4. Identification of FKBP11 as a biomarker for hepatocellular carcinoma. Lin IY, et al. Anticancer Res, 2013 Jun. PMID 23749938
  5. The human FK506-binding proteins: characterization of human FKBP19. Rulten SL, et al. Mamm Genome, 2006 Apr. PMID 16596453

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma.
    Title: FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma.
  2. FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma.
    Title: FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma.
  3. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
    Title: FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
  4. FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.
    Title: FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.
  5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate.
    Title: Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.
  6. results suggest a progressively elevated expression of FKBP11 during the development of hepatocellular carcinoma
    Title: Identification of FKBP11 as a biomarker for hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC54182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP11
Names
19 kDa FK506-binding protein
19 kDa FKBP
FK506 binding protein 11, 19 kDa
FK506-binding protein 11
FKBP-11
FKBP-19
PPIase FKBP11
rotamase
NP_001137253.1
NP_001137254.1
NP_057678.1
XP_047284895.1
XP_047284896.1
XP_054228172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143781.2 → NP_001137253.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2

    See identical proteins and their annotated locations for NP_001137253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC073610, AY358998, BE857354
    Consensus CDS
    CCDS44870.1
    UniProtKB/TrEMBL
    E9PAR0
    Related
    ENSP00000412403.2, ENST00000444214.6
    Conserved Domains (1) summary
    COG0545
    Location:1 → 40
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

  2. NM_001143782.2 → NP_001137254.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001137254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK301455
    Consensus CDS
    CCDS44871.1
    UniProtKB/Swiss-Prot
    Q9NYL4
    Related
    ENSP00000396874.2, ENST00000453172.2
    Conserved Domains (1) summary
    pfam00254
    Location:50 → 128
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  3. NM_016594.3 → NP_057678.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY358998
    Consensus CDS
    CCDS8773.1
    UniProtKB/Swiss-Prot
    B4DWB7, Q9NYL4
    Related
    ENSP00000449751.1, ENST00000550765.6
    Conserved Domains (1) summary
    pfam00254
    Location:50 → 141
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48921963..48939034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428939.1 → XP_047284895.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X1

  2. XM_047428940.1 → XP_047284896.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48884157..48887686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372197.1 → XP_054228172.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYL4.1 GenPept UniProtKB/Swiss-Prot:Q9NYL4

Gene LinkOut

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