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PTPN4 protein tyrosine phosphatase non-receptor type 4 [ Bos taurus (domestic cattle) ]

Gene ID: 512883, updated on 10-Oct-2024

Summary

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Official Symbol
PTPN4provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 4provided by VGNC
Primary source
VGNC:VGNC:33539
See related
BGD:BT17929; Ensembl:ENSBTAG00000020855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PTPN4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (71547187..71737731)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 221 Neighboring gene transmembrane protein 177 Neighboring gene uncharacterized LOC132343131 Neighboring gene tumor susceptibility gene 101 protein-like Neighboring gene kidney mitochondrial carrier protein 1-like Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene erythrocyte membrane protein band 4.1 like 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 4
Names
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NP_001179875.1
XP_024856776.1
XP_024856779.1
XP_024856780.1
XP_059749100.1
XP_059749103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192946.1 → NP_001179875.1  tyrosine-protein phosphatase non-receptor type 4

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000002
    UniProtKB/TrEMBL
    E1BJR7
    Related
    ENSBTAP00000042825.5, ENSBTAT00000045437.5
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:682 → 909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:515 → 602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    71547187..71737731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025001008.2 → XP_024856776.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    UniProtKB/TrEMBL
    E1BJR7
    Conserved Domains (5) summary
    smart00295
    Location:30 → 236
    B41; Band 4.1 homologues
    cd00047
    Location:696 → 923
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:529 → 616
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:230 → 324
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:339 → 379
    FA; FERM adjacent (FA)

  2. XM_059893120.1 → XP_059749103.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

  3. XM_025001011.2 → XP_024856779.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    UniProtKB/TrEMBL
    E1BJR7
    Conserved Domains (5) summary
    smart00295
    Location:30 → 229
    B41; Band 4.1 homologues
    cd00047
    Location:689 → 916
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:522 → 609
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:223 → 317
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:332 → 372
    FA; FERM adjacent (FA)

  4. XM_025001012.2 → XP_024856780.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

    UniProtKB/TrEMBL
    E1BJR7
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:682 → 909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:515 → 602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)

  5. XM_059893117.1 → XP_059749100.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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