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MARS1 methionyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 512531, updated on 4-Oct-2024

Summary

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Official Symbol
MARS1provided by VGNC
Official Full Name
methionyl-tRNA synthetase 1provided by VGNC
Primary source
VGNC:VGNC:31250
See related
BGD:BT25809; Ensembl:ENSBTAG00000018405
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
MARS
Orthologs
human mouse all
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Genomic context

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See MARS1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55960457..55979225, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DDIT3 upstream open reading frame protein Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA mir-2430 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI family zinc finger 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC134096

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methionine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methionine--tRNA ligase, cytoplasmic
Names
metRS
methionine-tRNA synthetase
methionyl-tRNA synthetase, cytoplasmic
NP_001033180.1
XP_024847411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038091.2 → NP_001033180.1  methionine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001033180.1

    Status: PROVISIONAL

    Source sequence(s)
    BC111362
    UniProtKB/Swiss-Prot
    Q2T9L8
    UniProtKB/TrEMBL
    A0A3Q1LLF2
    Related
    ENSBTAP00000057583.2, ENSBTAT00000080505.2
    Conserved Domains (7) summary
    cd07957
    Location:642 → 771
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:265 → 633
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    cd10307
    Location:77 → 179
    GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
    COG0625
    Location:47 → 189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    PRK12268
    Location:264 → 819
    PRK12268; methionyl-tRNA synthetase; Reviewed
    cd00939
    Location:843 → 887
    MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
    cl00388
    Location:27 → 68
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55960457..55979225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991643.2 → XP_024847411.1  methionine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LLF2, F1MDW1
    Related
    ENSBTAP00000024487.4, ENSBTAT00000024487.5
    Conserved Domains (2) summary
    cd10307
    Location:77 → 179
    GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
    cl26127
    Location:251 → 882
    PRK12267; methionyl-tRNA synthetase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2T9L8.1 GenPept UniProtKB/Swiss-Prot:Q2T9L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials