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MZB1 marginal zone B and B1 cell specific protein [ Homo sapiens (human) ]

Gene ID: 51237, updated on 18-Sep-2024

Summary

Official Symbol
MZB1provided by HGNC
Official Full Name
marginal zone B and B1 cell specific proteinprovided by HGNC
Primary source
HGNC:HGNC:30125
See related
Ensembl:ENSG00000170476 MIM:609447; AllianceGenome:HGNC:30125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACAP; pERp1; MEDA-7
Summary
Involved in positive regulation of cell population proliferation. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 68.4), urinary bladder (RPKM 65.2) and 13 other tissues See more
Orthologs
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Genomic context

See MZB1 in Genome Data Viewer
Location:
5q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139387467..139389913, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139913564..139916009, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138723156..138725602, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 64 Neighboring gene poly(A) binding protein interacting protein 2 Neighboring gene solute carrier family 23 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138716531-138717471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23229 Neighboring gene spermatogenesis associated 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23230 Neighboring gene proline rich basic protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739142-138739715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739716-138740288 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene uncharacterized LOC124901082

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ32987, MGC29506

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of endoplasmic reticulum chaperone complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
marginal zone B- and B1-cell-specific protein
Names
HSPC190
caspase-2 binding protein
mesenteric estrogen-dependent adipose 7
mesenteric oestrogen-dependent adipose gene- 7
plasma cell-induced ER protein 1
plasma cell-induced resident ER protein
plasma cell-induced resident endoplasmic reticulum protein
proapoptotic caspase adapter protein
proapoptotic caspase adaptor protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016459.4NP_057543.2  marginal zone B- and B1-cell-specific protein precursor

    See identical proteins and their annotated locations for NP_057543.2

    Status: VALIDATED

    Source sequence(s)
    AC135457, BC021275, BU601458
    Consensus CDS
    CCDS47273.1
    UniProtKB/Swiss-Prot
    D2IYS0, Q7Z6N2, Q8WU39, Q96RL5, Q9P0T3
    Related
    ENSP00000303920.8, ENST00000302125.9
    Conserved Domains (1) summary
    pfam11938
    Location:49172
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139387467..139389913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417264.1XP_047273220.1  marginal zone B- and B1-cell-specific protein isoform X1

    UniProtKB/TrEMBL
    B3KQ72

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    139913564..139916009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352721.1XP_054208696.1  marginal zone B- and B1-cell-specific protein isoform X1

    UniProtKB/TrEMBL
    B3KQ72
  2. XM_054352720.1XP_054208695.1  marginal zone B- and B1-cell-specific protein isoform X2