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COPZ2 COPI coat complex subunit zeta 2 [ Homo sapiens (human) ]

Gene ID: 51226, updated on 3-Apr-2024

Summary

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Official Symbol
COPZ2provided by HGNC
Official Full Name
COPI coat complex subunit zeta 2provided by HGNC
Primary source
HGNC:HGNC:19356
See related
Ensembl:ENSG00000005243 MIM:615526; AllianceGenome:HGNC:19356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
zeta2-COP
Summary
This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Expression
Broad expression in fat (RPKM 13.1), prostate (RPKM 4.4) and 22 other tissues See more
Orthologs
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Genomic context

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See COPZ2 in Genome Data Viewer
Location:
17q21.32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48026167..48048053, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48887980..48909899, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46103533..46115159, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46048841-46049468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46052765-46053265 Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46072377-46072975 Neighboring gene Sharpr-MPRA regulatory region 8372 Neighboring gene uncharacterized LOC124904017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46092391-46092892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46092893-46093392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46103594-46104152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46104153-46104709 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46105093-46105359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12323 Neighboring gene microRNA 10226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46124493-46125096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46125097-46125698 Neighboring gene microRNA 152 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46125699-46126300 Neighboring gene NFE2L1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46131609-46132468 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46133329-46134186 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46134187-46135046 Neighboring gene NFE2 like bZIP transcription factor 1 Neighboring gene chromobox 1 Neighboring gene RNA, U6 small nuclear 1201, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1. Shtutman M, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746916, Free PMC Article
  2. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. Yu W, et al. J Mol Biol, 2009 Mar 6. PMID 19167404
  3. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Sullivan BM, et al. Mol Biol Cell, 2000 Sep. PMID 10982407, Free PMC Article
  4. Identification and characterization of novel isoforms of COP I subunits. Futatsumori M, et al. J Biochem, 2000 Nov. PMID 11056392
  5. In vivo assembly of coatomer, the COP-I coat precursor. Lowe M, et al. J Biol Chem, 1996 Nov 29. PMID 8940050

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells.
    Title: Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.
  2. The solution structure of a truncated form (residues 1-149; zeta-COP149) of human zeta-COP (total 177 residues), is reported.
    Title: Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC23008

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPI vesicle coat NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cis-Golgi network NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
coatomer subunit zeta-2
Names
coatomer protein complex subunit zeta 2
nonclathrin coat protein zeta-COP
zeta-2 COP
zeta-2-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016429.4 → NP_057513.1  coatomer subunit zeta-2

    See identical proteins and their annotated locations for NP_057513.1

    Status: REVIEWED

    Source sequence(s)
    BC015924, BQ002984, HY179834
    Consensus CDS
    CCDS74092.1
    UniProtKB/Swiss-Prot
    Q9P299
    Related
    ENSP00000480707.1, ENST00000621465.5
    Conserved Domains (1) summary
    cd14829
    Location:47 → 178
    Zeta-COP; zeta subunit of the F-COPI complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    48026167..48048053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524874.3 → XP_011523176.1  coatomer subunit zeta-2 isoform X4

    Conserved Domains (1) summary
    cl38905
    Location:47 → 152
    longin-like; Longin-like domains

  2. XM_047436209.1 → XP_047292165.1  coatomer subunit zeta-2 isoform X5

    Related
    ENSP00000464484.1, ENST00000584955.5

  3. XM_047436207.1 → XP_047292163.1  coatomer subunit zeta-2 isoform X2

  4. XM_047436208.1 → XP_047292164.1  coatomer subunit zeta-2 isoform X3

  5. XM_047436206.1 → XP_047292162.1  coatomer subunit zeta-2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    48887980..48909899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316365.1 → XP_054172340.1  coatomer subunit zeta-2 isoform X4

  2. XM_054316366.1 → XP_054172341.1  coatomer subunit zeta-2 isoform X5

  3. XM_054316363.1 → XP_054172338.1  coatomer subunit zeta-2 isoform X2

  4. XM_054316364.1 → XP_054172339.1  coatomer subunit zeta-2 isoform X3

  5. XM_054316362.1 → XP_054172337.1  coatomer subunit zeta-2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P299.1 GenPept UniProtKB/Swiss-Prot:Q9P299

Gene LinkOut

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