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C1R complement C1r [ Bos taurus (domestic cattle) ]

Gene ID: 511581, updated on 10-Oct-2024

Summary

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Official Symbol
C1Rprovided by VGNC
Official Full Name
complement C1rprovided by VGNC
Primary source
VGNC:VGNC:56194
See related
BGD:BT20853; Ensembl:ENSBTAG00000008612
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human all
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Genomic context

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See C1R in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (103376575..103387592)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like Neighboring gene uncharacterized LOC101902570 Neighboring gene uncharacterized LOC112446757 Neighboring gene complement C1s Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
  2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC127774

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C1r subcomponent
Names
complement component 1, r subcomponent
NP_001029579.1
XP_005207185.1
XP_059742284.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034407.1 → NP_001029579.1  complement C1r subcomponent precursor

    See identical proteins and their annotated locations for NP_001029579.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103405
    UniProtKB/TrEMBL
    F1N0N3, Q3SYT3
    Conserved Domains (3) summary
    smart00042
    Location:27 → 138
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    pfam00431
    Location:193 → 302
    CUB; CUB domain
    pfam14670
    Location:160 → 189
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    103376575..103387592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005207128.4 → XP_005207185.1  complement C1r subcomponent isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MGP1
    Related
    ENSBTAP00000069754.2, ENSBTAT00000073935.2
    Conserved Domains (6) summary
    smart00020
    Location:471 → 705
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:35 → 146
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:472 → 708
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:317 → 379
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:201 → 310
    CUB; CUB domain
    pfam14670
    Location:168 → 197
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_059886301.1 → XP_059742284.1  complement C1r subcomponent isoform X2

    UniProtKB/TrEMBL
    A5D9E9
    Related
    ENSBTAP00000011362.4, ENSBTAT00000011362.5
Nucleotide Protein Strain
Heading Accession and Version

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