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DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 [ Homo sapiens (human) ]

Gene ID: 51143, updated on 11-Apr-2024

Summary

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Official Symbol
DYNC1LI1provided by HGNC
Official Full Name
dynein cytoplasmic 1 light intermediate chain 1provided by HGNC
Primary source
HGNC:HGNC:18745
See related
Ensembl:ENSG00000144635 MIM:615890; AllianceGenome:HGNC:18745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIC1; DLC-A; DLIC-1; DNCLI1
Summary
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 27.3), heart (RPKM 19.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p22.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (32525974..32570858, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (32522924..32567802, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32567466..32612350, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ay Neighboring gene ribosomal protein L31 pseudogene 18 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:32611558-32612343 Neighboring gene uncharacterized LOC124906226 Neighboring gene POLE4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer. Chang CC, et al. Mol Med Rep, 2020 Jul. PMID 32319648, Free PMC Article
  2. A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport. Celestino R, et al. PLoS Biol, 2019 Jan. PMID 30615611, Free PMC Article
  3. A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Lee IG, et al. Nat Commun, 2018 Mar 7. PMID 29515126, Free PMC Article
  4. Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division. Horgan CP, et al. Cell Biol Int, 2011 Feb. PMID 20964624
  5. Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions. Kumari A, et al. J Cell Biol, 2021 Dec 6. PMID 34709360, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.
    Title: Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.
  2. Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
    Title: Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
  3. Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
    Title: Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
  4. High DLIC1 expression is associated with colon cancer
    Title: DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells.
  5. conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility
    Title: A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.
  6. the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons.
    Title: Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.
  7. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes.
    Title: Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
  8. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle.
    Title: Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.
  9. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway.
    Title: Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.
  10. Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells.
    Title: Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, light intermediate chain 1 (DYNC1LI1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to recycling endosome transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic dynein 1 light intermediate chain 1
Names
dynein light chain A
dynein light intermediate chain 1, cytosolic
dynein, cytoplasmic, light intermediate polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051046.1 RefSeqGene

    Range
    5067..49951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329135.2 → NP_001316064.1  cytoplasmic dynein 1 light intermediate chain 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK074348
    Consensus CDS
    CCDS87058.1
    UniProtKB/TrEMBL
    B4DDM4, E9PHI6
    Related
    ENSP00000407279.2, ENST00000432458.6
    Conserved Domains (1) summary
    pfam05783
    Location:43 → 403
    DLIC; Dynein light intermediate chain (DLIC)

  2. NM_016141.4 → NP_057225.2  cytoplasmic dynein 1 light intermediate chain 1 isoform 1

    See identical proteins and their annotated locations for NP_057225.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074348
    Consensus CDS
    CCDS2654.1
    UniProtKB/Swiss-Prot
    A2RRG7, Q53HC8, Q53HK7, Q9Y6G9
    Related
    ENSP00000273130.4, ENST00000273130.9
    Conserved Domains (1) summary
    pfam05783
    Location:43 → 517
    DLIC; Dynein light intermediate chain (DLIC)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    32525974..32570858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448246.1 → XP_047304202.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

    UniProtKB/TrEMBL
    B3KM42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    32522924..32567802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346721.1 → XP_054202696.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

    UniProtKB/TrEMBL
    B3KM42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6G9.3 GenPept UniProtKB/Swiss-Prot:Q9Y6G9

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