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METTL9 methyltransferase 9, His-X-His N1(pi)-histidine [ Homo sapiens (human) ]

Gene ID: 51108, updated on 30-Mar-2024

Summary

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Official Symbol
METTL9provided by HGNC
Official Full Name
methyltransferase 9, His-X-His N1(pi)-histidineprovided by HGNC
Primary source
HGNC:HGNC:24586
See related
Ensembl:ENSG00000197006 MIM:609388; AllianceGenome:HGNC:24586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DREV; PAP1; DREV1; CGI-81; hMETTL9
Summary
Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16p12.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (21597208..21657471)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (22559463..22619737, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21608529..21668792)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:21529065-21529231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21531393-21532126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532127-21532859 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532860-21533594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21535062-21535794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21536490-21537300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21537301-21538111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21538112-21538922 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43111 Neighboring gene solute carrier family 7 member 5 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549325-21549826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549827-21550326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21552333-21553071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10557 Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21561118-21561618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21562361-21562862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21565604-21566414 Neighboring gene uncharacterized LOC101927814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7257 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21611613-21612177 Neighboring gene uncharacterized LOC124903663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10558 Neighboring gene RNA, U6 small nuclear 1005, pseudogene Neighboring gene RNA, U6 small nuclear 196, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10559 Neighboring gene immunoglobulin superfamily member 6 Neighboring gene otoancorin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10560 Neighboring gene uncharacterized LOC105371126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21801669-21802169

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Lv M, et al. Protein Cell, 2021 Dec. PMID 34218407, Free PMC Article
  2. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, et al. Nat Commun, 2021 Feb 9. PMID 33563959, Free PMC Article
  3. Effects of exogenous p53 transfection on the gene expression in the human brain glioma cell line U251. Shu KX, et al. Colloids Surf B Biointerfaces, 2006 Feb 1. PMID 16413759
  4. siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9. Daitoku H, et al. J Biol Chem, 2021 Nov. PMID 34562450, Free PMC Article
  5. Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development. Shu KX, et al. Colloids Surf B Biointerfaces, 2006 Sep 1. PMID 16837177

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
    Title: METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
  2. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
    Title: METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
  3. siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.
    Title: siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
  4. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
    Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  6. cloned the PAP1 gene, a p53 activated protein, from a U251-pTet-p53 cell line which carried a wild-type p53 transgene.
    Title: Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-L-histidine N-pros-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-L-histidine N-pros-methyltransferase
Names
CTB-31N19.3
DORA reverse strand protein 1
methyltransferase 9, His-X-His N1-histidine
methyltransferase like 9
methyltransferase-like protein 9
p53 activated protein 1
NP_001070648.1
NP_001275588.1
NP_001275589.1
NP_057109.3
XP_054188124.1
XP_054236409.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077180.3 → NP_001070648.1  protein-L-histidine N-pros-methyltransferase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AJ278578, BC000195
    Consensus CDS
    CCDS45440.1
    UniProtKB/TrEMBL
    B2R7Q6
    Related
    ENSP00000379335.4, ENST00000396014.8
    Conserved Domains (1) summary
    pfam05219
    Location:56 → 316
    DREV; DREV methyltransferase

  2. NM_001288659.2 → NP_001275588.1  protein-L-histidine N-pros-methyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001275588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005632, BC000195, BG183771
    UniProtKB/TrEMBL
    Q8TD49
    Related
    ENSP00000454733.1, ENST00000567404.5
    Conserved Domains (1) summary
    pfam05219
    Location:16 → 277
    DREV; DREV methyltransferase

  3. NM_001288660.2 → NP_001275589.1  protein-L-histidine N-pros-methyltransferase isoform 4

    See identical proteins and their annotated locations for NP_001275589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005632, AJ278578, BC000195, BG183771
    UniProtKB/TrEMBL
    Q8TD49
    Conserved Domains (1) summary
    pfam05219
    Location:16 → 276
    DREV; DREV methyltransferase

  4. NM_016025.5 → NP_057109.3  protein-L-histidine N-pros-methyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_057109.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC000195, CF146931
    Consensus CDS
    CCDS10598.2
    UniProtKB/Swiss-Prot
    Q8NBT8, Q9BWJ7, Q9H1A2, Q9H1A3, Q9Y390
    UniProtKB/TrEMBL
    B2R7Q6
    Related
    ENSP00000350874.3, ENST00000358154.8
    Conserved Domains (1) summary
    pfam05219
    Location:56 → 317
    DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    21597208..21657471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p14 PATCHES

    Range
    1447357..1507609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332149.1 → XP_054188124.1  protein-L-histidine N-pros-methyltransferase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    22559463..22619737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380434.1 → XP_054236409.1  protein-L-histidine N-pros-methyltransferase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H1A3.1 GenPept UniProtKB/Swiss-Prot:Q9H1A3

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