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ZC2HC1A zinc finger C2HC-type containing 1A [ Homo sapiens (human) ]

Gene ID: 51101, updated on 7-Apr-2024

Summary

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Official Symbol
ZC2HC1Aprovided by HGNC
Official Full Name
zinc finger C2HC-type containing 1Aprovided by HGNC
Primary source
HGNC:HGNC:24277
See related
Ensembl:ENSG00000104427 AllianceGenome:HGNC:24277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-62; C8orf70; FAM164A
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 5.6), thyroid (RPKM 3.9) and 22 other tissues See more
Orthologs
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Genomic context

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See ZC2HC1A in Genome Data Viewer
Location:
8q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (78666089..78719765)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (79097623..79151232)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (79578324..79632000)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375911 Neighboring gene RNA, U6 small nuclear 1220, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:79350973-79351621 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:79357423-79358019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27545 Neighboring gene PKIA antisense RNA 1 Neighboring gene cAMP-dependent protein kinase inhibitor alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:79577447-79577955 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:79577956-79578463 Neighboring gene interleukin 7 Neighboring gene C4orf46 pseudogene 3 Neighboring gene THAP domain containing 12 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A new role for FBP21 as regulator of Brr2 helicase activity. Henning LM, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28838205, Free PMC Article
  2. Impact of WIN site inhibitor on the WDR5 interactome. Guarnaccia AD, et al. Cell Rep, 2021 Jan 19. PMID 33472061, Free PMC Article
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  4. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
zinc finger C2HC domain-containing protein 1A
Names
family with sequence similarity 164, member A
protein FAM164A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362969.2 → NP_001349898.1  zinc finger C2HC domain-containing protein 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100854, AK313723, BI600862, BU075578, DA137885
    Consensus CDS
    CCDS94321.1
    UniProtKB/TrEMBL
    B2R9B8, H0YAP0
    Related
    ENSP00000427797.2, ENST00000519307.2
    Conserved Domains (1) summary
    pfam13913
    Location:15 → 39
    zf-C2HC_2; zinc-finger of a C2HC-type

  2. NM_016010.3 → NP_057094.2  zinc finger C2HC domain-containing protein 1A isoform 1

    See identical proteins and their annotated locations for NP_057094.2

    Status: VALIDATED

    Source sequence(s)
    AC100854, AK313723, BU075578, DA137885
    Consensus CDS
    CCDS6223.1
    UniProtKB/Swiss-Prot
    Q96GY0, Q9Y372
    UniProtKB/TrEMBL
    B2R9B8
    Related
    ENSP00000263849.3, ENST00000263849.9
    Conserved Domains (1) summary
    pfam13913
    Location:15 → 39
    zf-C2HC_2; zinc-finger of a C2HC-type

RNA

  1. NR_156423.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC100854, AK313723, BI600862, BU075578, DA137885

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    78666089..78719765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517539.4 → XP_011515841.1  zinc finger C2HC domain-containing protein 1A isoform X1

    UniProtKB/TrEMBL
    A0A994J7X1
    Related
    ENSP00000516191.1, ENST00000705981.1
    Conserved Domains (1) summary
    pfam13913
    Location:15 → 39
    zf-C2HC_2; zinc-finger of a C2HC-type

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    79097623..79151232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360552.1 → XP_054216527.1  zinc finger C2HC domain-containing protein 1A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GY0.2 GenPept UniProtKB/Swiss-Prot:Q96GY0

Gene LinkOut

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