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ZNF691 zinc finger protein 691 [ Homo sapiens (human) ]

Gene ID: 51058, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF691provided by HGNC
Official Full Name
zinc finger protein 691provided by HGNC
Primary source
HGNC:HGNC:28028
See related
Ensembl:ENSG00000164011 AllianceGenome:HGNC:28028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp691
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.2), ovary (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (42846613..42852477)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (42717094..42722959)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43312284..43318148)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene erythroblast membrane associated protein (Scianna blood group) Neighboring gene uncharacterized LOC124904163 Neighboring gene ZNF691 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 898 Neighboring gene uncharacterized LOC339539 Neighboring gene transmembrane channel like 6 pseudogene Neighboring gene makorin ring finger protein 8, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
  2. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
  3. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 691

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242739.2 → NP_001229668.1  zinc finger protein 691 isoform 1

    See identical proteins and their annotated locations for NP_001229668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF131739, BM741761, DC378862
    Consensus CDS
    CCDS55595.1
    UniProtKB/Swiss-Prot
    A8MXP6, B4DJR7, O95878, Q5VV52, Q9NWE8
    Related
    ENSP00000498913.1, ENST00000651192.1
    Conserved Domains (3) summary
    COG5048
    Location:108 → 266
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229 → 249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283 → 305
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_015911.4 → NP_056995.1  zinc finger protein 691 isoform 2

    See identical proteins and their annotated locations for NP_056995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF131739
    Consensus CDS
    CCDS476.1
    UniProtKB/Swiss-Prot
    Q5VV52
    Related
    ENSP00000361586.3, ENST00000372508.7
    Conserved Domains (4) summary
    COG5048
    Location:77 → 235
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252 → 274
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:98 → 123
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    42846613..42852477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421903.1 → XP_047277859.1  zinc finger protein 691 isoform X3

    UniProtKB/TrEMBL
    Q5VV50
    Related
    ENSP00000486871.1, ENST00000630961.1

  2. XM_017001402.3 → XP_016856891.1  zinc finger protein 691 isoform X3

    UniProtKB/TrEMBL
    Q5VV50
    Conserved Domains (4) summary
    COG5048
    Location:99 → 257
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:274 → 296
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:120 → 145
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047421910.1 → XP_047277866.1  zinc finger protein 691 isoform X3

    UniProtKB/TrEMBL
    Q5VV50
    Related
    ENSP00000361582.1, ENST00000372504.5

  4. XM_006710671.5 → XP_006710734.1  zinc finger protein 691 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:104 → 262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279 → 301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:125 → 150
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047421899.1 → XP_047277855.1  zinc finger protein 691 isoform X1

    UniProtKB/Swiss-Prot
    A8MXP6, B4DJR7, O95878, Q5VV52, Q9NWE8
    Related
    ENSP00000361581.2, ENST00000372503.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    42717094..42722959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336866.1 → XP_054192841.1  zinc finger protein 691 isoform X3

  2. XM_054336868.1 → XP_054192843.1  zinc finger protein 691 isoform X3

  3. XM_054336865.1 → XP_054192840.1  zinc finger protein 691 isoform X2

  4. XM_054336864.1 → XP_054192839.1  zinc finger protein 691 isoform X1

  5. XM_054336867.1 → XP_054192842.1  zinc finger protein 691 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VV52.2 GenPept UniProtKB/Swiss-Prot:Q5VV52

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