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PI15 peptidase inhibitor 15 [ Homo sapiens (human) ]

Gene ID: 51050, updated on 5-Mar-2024

Summary

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Official Symbol
PI15provided by HGNC
Official Full Name
peptidase inhibitor 15provided by HGNC
Primary source
HGNC:HGNC:8946
See related
Ensembl:ENSG00000137558 MIM:607076; AllianceGenome:HGNC:8946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P24TI; P25TI; CRISP8
Summary
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 36.9), prostate (RPKM 13.1) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
8q21.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (74824534..74855029)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (75254011..75284508)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (75736769..75767264)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MIR2052 host gene Neighboring gene long intergenic non-protein coding RNA 3071 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:75560326-75560913 Neighboring gene microRNA 2052 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:75720049-75720586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:75859985-75860622 Neighboring gene cysteine rich secretory protein LCCL domain containing 1 Neighboring gene uncharacterized LOC124901964 Neighboring gene uncharacterized LOC105375905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:76042510-76043087

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. Jiang Y, et al. EBioMedicine, 2019 Feb. PMID 30638862, Free PMC Article
  2. Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity. Prusty BK, et al. Front Cell Infect Microbiol, 2018. PMID 29900129, Free PMC Article
  3. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. Yamakawa T, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473672
  4. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. Koshikawa N, et al. J Biochem, 1996 Feb. PMID 8882727
  5. A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor. Kaplan F, et al. Am J Physiol, 1999 Jun. PMID 10362728

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidase inhibitor 15
Names
25 kDa trypsin inhibitor
CRISP-8
PI-15
cysteine-rich secretory protein 8
protease inhibitor 15
sugarCrisp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324403.2 → NP_001311332.1  peptidase inhibitor 15 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC011632, AC026616
    Consensus CDS
    CCDS6218.1
    UniProtKB/Swiss-Prot
    O43692, Q68CY1
    Related
    ENSP00000497041.1, ENST00000649643.1
    Conserved Domains (1) summary
    cd18814
    Location:67 → 212
    CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15

  2. NM_015886.5 → NP_056970.1  peptidase inhibitor 15 preproprotein

    See identical proteins and their annotated locations for NP_056970.1

    Status: REVIEWED

    Source sequence(s)
    AC011632, AC026616, CR749657, D45027
    Consensus CDS
    CCDS6218.1
    UniProtKB/Swiss-Prot
    O43692, Q68CY1
    Related
    ENSP00000260113.2, ENST00000260113.7
    Conserved Domains (1) summary
    cd18814
    Location:67 → 212
    CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    74824534..74855029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    75254011..75284508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43692.1 GenPept UniProtKB/Swiss-Prot:O43692

Gene LinkOut

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