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PPP2R2B protein phosphatase 2 regulatory subunit Bbeta [ Bos taurus (domestic cattle) ]

Gene ID: 509290, updated on 12-Oct-2024

Summary

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Official Symbol
PPP2R2Bprovided by VGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bbetaprovided by VGNC
Primary source
VGNC:VGNC:33256
See related
BGD:BT21276; Ensembl:ENSBTAG00000001862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PPP2R2B in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (57796200..58305681, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447556 Neighboring gene G protein-coupled receptor 151 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene serine/threonine kinase 32A Neighboring gene microRNA mir-2284y-7 Neighboring gene dihydropyrimidinase like 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C. Ching LC, et al. Acta Physiol (Oxf), 2013 Oct. PMID 24028645
  2. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. Sontag JM, et al. J Biol Chem, 2012 Apr 27. PMID 22403409, Free PMC Article
  3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPV1 activation in endothelial cells may elicit a Ca(2+) -dependent effect on PP2B-PKC signalling, which leads to dephosphorylation of eNOS
    Title: Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.
  2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
    Title: The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC139491

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
BRbeta B-regulatory subunit of protein phosphatase 2A
protein phosphatase 2, regulatory subunit B, beta
NP_001259014.1
XP_010805741.1
XP_010805747.1
XP_015327783.1
XP_059744032.1
XP_059744033.1
XP_059744034.1
XP_059744035.1
XP_059744036.1
XP_059744037.1
XP_059744038.1
XP_059744039.1
XP_059744040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272085.1 → NP_001259014.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

    See identical proteins and their annotated locations for NP_001259014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    BT020863, DV835023, EH146888, EH376346
    UniProtKB/TrEMBL
    A0A3Q1M5E1, A0A3Q1M9B9
    Related
    ENSBTAP00000065034.2, ENSBTAT00000083608.2
    Conserved Domains (2) summary
    COG5170
    Location:14 → 444
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:33 → 81
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_073586.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC118167
    Related
    ENSBTAT00000002427.4

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    57796200..58305681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888050.1 → XP_059744033.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

  2. XM_059888051.1 → XP_059744034.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X4

    UniProtKB/TrEMBL
    A0AAA9S0F3
    Related
    ENSBTAP00000078444.1, ENSBTAT00000100343.1

  3. XM_010807439.3 → XP_010805741.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

    See identical proteins and their annotated locations for XP_010805741.1

    UniProtKB/TrEMBL
    A0A3Q1M5E1, A0AAA9SP76
    Related
    ENSBTAP00000088118.1, ENSBTAT00000104122.1
    Conserved Domains (2) summary
    COG5170
    Location:88 → 504
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:93 → 141
    7WD40; WD40 repeat [structural motif]

  4. XM_059888049.1 → XP_059744032.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

  5. XM_010807445.4 → XP_010805747.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

    See identical proteins and their annotated locations for XP_010805747.1

    UniProtKB/TrEMBL
    A0A3Q1N515, A0AAA9SBE3
    Related
    ENSBTAP00000081215.1, ENSBTAT00000111445.1
    Conserved Domains (2) summary
    COG5170
    Location:25 → 441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 78
    7WD40; WD40 repeat [structural motif]

  6. XM_059888056.1 → XP_059744039.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X9

    UniProtKB/TrEMBL
    A0A3Q1MH72
    Related
    ENSBTAP00000068406.1, ENSBTAT00000067103.2

  7. XM_059888055.1 → XP_059744038.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X8

  8. XM_059888053.1 → XP_059744036.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

  9. XM_059888057.1 → XP_059744040.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X11

  10. XM_059888052.1 → XP_059744035.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MJU7
    Related
    ENSBTAP00000071664.2, ENSBTAT00000074552.2

  11. XM_059888054.1 → XP_059744037.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

  12. XM_015472297.2 → XP_015327783.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X10

    UniProtKB/TrEMBL
    A0A3Q1N515
    Conserved Domains (3) summary
    COG5170
    Location:3 → 416
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:5 → 53
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:168 → 412
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014879.2: Suppressed sequence

    Description
    NM_001014879.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5E9Q7.1 GenPept UniProtKB/Swiss-Prot:Q5E9Q7

Gene LinkOut

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Molecular Biology Databases
Research Materials