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CSK C-terminal Src kinase [ Bos taurus (domestic cattle) ]

Gene ID: 509246, updated on 12-Oct-2024

Summary

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Official Symbol
CSKprovided by VGNC
Official Full Name
C-terminal Src kinaseprovided by VGNC
Primary source
VGNC:VGNC:27761
See related
BGD:BT28189; Ensembl:ENSBTAG00000021424
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CSK in Genome Data Viewer
Location:
chromosome: 21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (33873767..33892160, complement)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene complexin 3 Neighboring gene lectin, mannose binding 1 like Neighboring gene uncharacterized LOC101903178 Neighboring gene cytochrome P450 family 1 subfamily A member 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity. Chang R, et al. Am J Physiol Lung Cell Mol Physiol, 2008 Oct. PMID 18621907, Free PMC Article
  2. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. Itoh S, et al. J Biol Chem, 2005 Jul 15. PMID 15855164
  3. Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Pan S, et al. Arterioscler Thromb Vasc Biol, 2009 Jun. PMID 19359662
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
    Title: Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
  2. Src family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase in pulmonary artery endothelium.
    Title: Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.
  3. Dok-4 has a role as an anchoring molecule for the tyrosine kinase c-Src, and in turn as a regulator of TNF-alpha-mediated ROS production and NF-kappaB activation
    Title: Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC142896

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase CSK
Names
C-SRC kinase
CSK, non-receptor tyrosine kinase
c-src tyrosine kinase
NP_001068865.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075397.1 → NP_001068865.1  tyrosine-protein kinase CSK

    See identical proteins and their annotated locations for NP_001068865.1

    Status: PROVISIONAL

    Source sequence(s)
    BC120437
    UniProtKB/Swiss-Prot
    Q0VBZ0
    UniProtKB/TrEMBL
    A0A3Q1MM24
    Related
    ENSBTAP00000028559.4, ENSBTAT00000028559.5
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33873767..33892160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VBZ0.1 GenPept UniProtKB/Swiss-Prot:Q0VBZ0

Gene LinkOut

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