Grb14 growth factor receptor bound protein 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grb14provided by MGI
Official Full Name: growth factor receptor bound protein 14provided by MGI
Primary source: MGI:MGI:1355324
See related: Ensembl:ENSMUSG00000026888 AllianceGenome:MGI:1355324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein-macromolecule adaptor activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within signal transduction. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in forebrain; ganglia; male reproductive gland or organ; and nucleus pulposus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 19.5), ovary adult (RPKM 12.9) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 38.35 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (64742820..64853143, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (64912476..65022766, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14.
Title: Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14.
Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction.
Title: Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction.
Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.
Title: Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance.
The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling.
Title: Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation.
Data show that Grb14 inhibits the activity of PTP1B in retina in a phosphorylation-regulated manner, and that rhodopsin-regulated Src kinase activation in retina leads to the phosphorylation of Grb14.
Title: Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.
Grb14 is a normal physiological modulator of CNG channel function in vivo.
Title: Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.
Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis
Title: Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.
These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.
Title: Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
Grb14 exerts a dual role on the regulation by insulin of hepatic metabolism. It inhibits insulin receptor catalytic activity, and as a sterol regulatory element binding protein-1c maturation.
Title: Dual effect of the adapter growth factor receptor-bound protein 14 (grb14) on insulin action in primary hepatocytes.
regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity
Title: Increased adipose tissue expression of Grb14 in several models of insulin resistance.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth factor receptor-bound protein 14

Names: GRB14 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412538.1 → NP_001399467.1 growth factor receptor-bound protein 14 isoform 2

Status: VALIDATED

Source sequence(s)

AL928703, AL929129
NM_001412539.1 → NP_001399468.1 growth factor receptor-bound protein 14 isoform 3

Status: VALIDATED

Source sequence(s)

AL928703, AL929129
NM_001412540.1 → NP_001399469.1 growth factor receptor-bound protein 14 isoform 4

Status: VALIDATED

Source sequence(s)

AL928703, AL929129
NM_016719.2 → NP_057928.1 growth factor receptor-bound protein 14 isoform 1

See identical proteins and their annotated locations for NP_057928.1

Status: VALIDATED

Source sequence(s)

AL928703, AL929129

Consensus CDS

CCDS16071.1

UniProtKB/Swiss-Prot

Q3UI77, Q8VDI2, Q9CR03, Q9JLM9

UniProtKB/TrEMBL

A2ASX2

Related

ENSMUSP00000028252.8, ENSMUST00000028252.14

Conserved Domains (5) summary

cd01787
Location:104 → 188

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10414
Location:431 → 538

SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins

cd01259
Location:228 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam00169
Location:233 → 339

PH; PH domain

pfam08947
Location:368 → 412

BPS; BPS (Between PH and SH2)