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Olig2 oligodendrocyte transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 50913, updated on 5-Nov-2024

Summary

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Official Symbol
Olig2provided by MGI
Official Full Name
oligodendrocyte transcription factor 2provided by MGI
Primary source
MGI:MGI:1355331
See related
Ensembl:ENSMUSG00000039830 AllianceGenome:MGI:1355331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and sensory organ. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 9.5), cortex adult (RPKM 8.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Olig2 in Genome Data Viewer
Location:
16 C3.3; 16 52.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91016745..91025567)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91225550..91228677)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41492 Neighboring gene predicted gene 9881 Neighboring gene STARR-seq mESC enhancer starr_41474 Neighboring gene predicted gene, 53920 Neighboring gene predicted gene, 52261 Neighboring gene oligodendrocyte transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_41475 Neighboring gene STARR-seq mESC enhancer starr_41476 Neighboring gene STARR-positive B cell enhancer ABC_E5559 Neighboring gene predicted gene, 24695

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ultraconserved elements in the Olig2 promoter. Chen CT, et al. PLoS One, 2008. PMID 19079603, Free PMC Article
  2. Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus. Benner B, et al. J Neurovirol, 2016 Jun. PMID 26631080
  3. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice. Chen X, et al. Neurosci Bull, 2020 Apr. PMID 31758330, Free PMC Article
  4. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. Meijer DH, et al. J Neurosci, 2014 Jun 18. PMID 24948806, Free PMC Article
  5. Cortical astrocytes develop in a plastic manner at both clonal and cellular levels. Clavreul S, et al. Nat Commun, 2019 Oct 25. PMID 31653848, Free PMC Article

See all (884) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. bHLH transcription factors Hes1, Ascl1 and Oligo2 exhibit different expression patterns in the process of physiological electric fields-induced neuronal differentiation.
    Title: bHLH transcription factors Hes1, Ascl1 and Oligo2 exhibit different expression patterns in the process of physiological electric fields-induced neuronal differentiation.
  2. OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse.
    Title: OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse.
  3. Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities.
    Title: Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities.
  4. Disruption of the anterior commissure in Olig2 deficient mice.
    Title: Disruption of the anterior commissure in Olig2 deficient mice.
  5. Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.
    Title: Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.
  6. OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
    Title: OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
  7. The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
    Title: The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
  8. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.
    Title: Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.
  9. Effects of taxol on neuronal differentiation of postnatal neural stem cells cultured from mouse subventricular zone.
    Title: Effects of taxol on neuronal differentiation of postnatal neural stem cells cultured from mouse subventricular zone.
  10. Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
    Title: Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (9)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables HMG box domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thalamus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
oligodendrocyte transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016967.2 → NP_058663.2  oligodendrocyte transcription factor 2

    See identical proteins and their annotated locations for NP_058663.2

    Status: VALIDATED

    Source sequence(s)
    BC051967
    Consensus CDS
    CCDS28323.1
    UniProtKB/Swiss-Prot
    Q9EQW6, Q9JKN4
    UniProtKB/TrEMBL
    Q542S0
    Related
    ENSMUSP00000036797.9, ENSMUST00000035608.10
    Conserved Domains (1) summary
    cd18940
    Location:95 → 179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91016745..91025567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160000.1 → XP_036015893.1  oligodendrocyte transcription factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQW6, Q9JKN4
    UniProtKB/TrEMBL
    Q542S0
    Conserved Domains (1) summary
    cd18940
    Location:95 → 179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQW6.1 GenPept UniProtKB/Swiss-Prot:Q9EQW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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