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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Bos taurus (domestic cattle) ]

Gene ID: 509106, updated on 10-Oct-2024

Summary

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Official Symbol
EZH2provided by VGNC
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by VGNC
Primary source
VGNC:VGNC:28675
See related
BGD:BT10727; Ensembl:ENSBTAG00000009426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See EZH2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (112024328..112081434, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene contactin associated protein 2 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC100336368 Neighboring gene cullin 1 Neighboring gene zinc finger protein 786 Neighboring gene protein disulfide isomerase family A member 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K27 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
NP_001179953.1
XP_015326242.1
XP_024846348.1
XP_024846349.1
XP_059741475.1
XP_059741476.1
XP_059741477.1
XP_059741478.1
XP_059741479.1
XP_059741480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193024.1 → NP_001179953.1  histone-lysine N-methyltransferase EZH2

    See identical proteins and their annotated locations for NP_001179953.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000004
    UniProtKB/TrEMBL
    A0A3Q1MSK4
    Related
    ENSBTAP00000012405.6, ENSBTAT00000012405.7
    Conserved Domains (4) summary
    cd19218
    Location:614 → 733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564 → 595
    preSET_CXC; CXC domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    112024328..112081434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015470756.3 → XP_015326242.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1MSK4
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  2. XM_059885493.1 → XP_059741476.1  histone-lysine N-methyltransferase EZH2 isoform X4

  3. XM_059885496.1 → XP_059741479.1  histone-lysine N-methyltransferase EZH2 isoform X8

  4. XM_059885494.1 → XP_059741477.1  histone-lysine N-methyltransferase EZH2 isoform X5

  5. XM_059885492.1 → XP_059741475.1  histone-lysine N-methyltransferase EZH2 isoform X3

  6. XM_024990581.2 → XP_024846349.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MSK4, A0AAA9THU3
    Related
    ENSBTAP00000098088.1, ENSBTAT00000105975.1
    Conserved Domains (2) summary
    smart00317
    Location:623 → 744
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:50 → 78
    EZH2_WD-Binding; WD repeat binding protein EZH2

  7. XM_059885495.1 → XP_059741478.1  histone-lysine N-methyltransferase EZH2 isoform X7

  8. XM_024990580.2 → XP_024846348.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MSK4
    Conserved Domains (2) summary
    smart00317
    Location:628 → 749
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:50 → 78
    EZH2_WD-Binding; WD repeat binding protein EZH2

  9. XM_059885497.1 → XP_059741480.1  histone-lysine N-methyltransferase EZH2 isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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