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Ntm neurotrimin [ Rattus norvegicus (Norway rat) ]

Gene ID: 50864, updated on 2-Nov-2024

Summary

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Official Symbol
Ntmprovided by RGD
Official Full Name
neurotriminprovided by RGD
Primary source
RGD:620958
See related
EnsemblRapid:ENSRNOG00000066437 AllianceGenome:RGD:620958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnt; GP65; RNU16845
Summary
Involved in cerebellum development; negative regulation of neuron projection development; and response to estradiol. Located in several cellular components, including cell surface; excitatory synapse; and perinuclear region of cytoplasm. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic active zone membrane. Orthologous to human NTM (neurotrimin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 349.3) and Uterus (RPKM 15.2) See more
Orthologs
human mouse all
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Genomic context

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See Ntm in Genome Data Viewer
Location:
8q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (35634929..36625081, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (27376582..28366604, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (30039332..31041755, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480005 Neighboring gene opioid binding protein/cell adhesion molecule-like Neighboring gene endothelial differentiation-related factor 1, pseudogene 1 Neighboring gene uncharacterized LOC120094318 Neighboring gene uncharacterized LOC134480150 Neighboring gene uncharacterized LOC120094317 Neighboring gene uncharacterized LOC134480151 Neighboring gene uncharacterized LOC134480006 Neighboring gene uncharacterized LOC108351666 Neighboring gene uncharacterized LOC134480007

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis. Chen S, et al. J Neurocytol, 2001 Nov. PMID 12373100
  2. Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP. Gil OD, et al. J Neurobiol, 2002 Jun 5. PMID 11984841
  3. Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry. Itoh S, et al. Biochemistry, 2008 Sep 23. PMID 18729387
  4. Neurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation. Krizsan-Agbas D, et al. J Neurosci Res, 2008 Nov 1. PMID 18627025, Free PMC Article
  5. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sanz RL, et al. Sci Rep, 2017 Aug 11. PMID 28801670, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurotrimin and LSAMP were identified as ADAM10 substrates that are shed from the cell surface of dorsal root ganglion (DRGs) neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons. Furthermore, LSAMP loss of function decreases the outgrowth sensitivity to an ADAM10 inhibitor.
    Title: Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.
  2. a role for neurotrimin in mediating estrogen-induced sympathetic pruning in some peripheral targets.
    Title: Neurotrimin is an estrogen-regulated determinant of peripheral sympathetic innervation.
  3. The spatio-temporal expression pattern of neurotrimin suggests that it plays a role in axonal fasciculation of specific cerebellar systems and may also be involved in the formation of excitatory synapses and their stabilization into adulthood.
    Title: Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis.
  4. homophilic and heterophilic interactions between IgLON family members are likely to play a role in the specification of neuronal projections via growth promoting and inhibiting effects, respectively.
    Title: Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neurotrimin
Names
protein CEPU-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431454.1 → NP_001418383.1  neurotrimin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  2. NM_001431455.1 → NP_001418384.1  neurotrimin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001431456.1 → NP_001418385.1  neurotrimin isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  4. NM_001431457.1 → NP_001418386.1  neurotrimin isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  5. NM_001431458.1 → NP_001418387.1  neurotrimin isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  6. NM_001431459.1 → NP_001418388.1  neurotrimin isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  7. NM_001431460.1 → NP_001418389.1  neurotrimin isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6GEH9

  8. NM_001431461.1 → NP_001418390.1  neurotrimin isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  9. NM_017354.3 → NP_059050.2  neurotrimin isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q62718
    UniProtKB/TrEMBL
    A0A8I6AE09, A6JYE7
    Conserved Domains (3) summary
    pfam13927
    Location:136 → 205
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:223 → 307
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    35634929..36625081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082005.2 → XP_038937933.1  neurotrimin isoform X3

    Conserved Domains (3) summary
    pfam13927
    Location:136 → 205
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:223 → 307
    Ig; Immunoglobulin domain

  2. XM_039082007.2 → XP_038937935.1  neurotrimin isoform X4

    Related
    ENSRNOP00000085993.1, ENSRNOT00000107198.2
    Conserved Domains (3) summary
    pfam13927
    Location:136 → 205
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:223 → 307
    Ig; Immunoglobulin domain

  3. XM_017595865.3 → XP_017451354.1  neurotrimin isoform X1

    Related
    ENSRNOP00000099382.1, ENSRNOT00000135693.1
    Conserved Domains (3) summary
    pfam13927
    Location:136 → 205
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:223 → 307
    Ig; Immunoglobulin domain

  4. XM_039082006.2 → XP_038937934.1  neurotrimin isoform X2

    Related
    ENSRNOP00000090247.2, ENSRNOT00000094487.2
    Conserved Domains (3) summary
    pfam13927
    Location:136 → 205
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:223 → 307
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62718.1 GenPept UniProtKB/Swiss-Prot:Q62718

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