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SNHG32 small nucleolar RNA host gene 32 [ Homo sapiens (human) ]

Gene ID: 50854, updated on 5-Mar-2024

Summary

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Official Symbol
SNHG32provided by HGNC
Official Full Name
small nucleolar RNA host gene 32provided by HGNC
Primary source
HGNC:HGNC:19078
See related
Ensembl:ENSG00000204387 MIM:605447; AllianceGenome:HGNC:19078
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G8; D6S57; C6orf48
Summary
Predicted to enable double-stranded RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 167.3), thyroid (RPKM 84.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
6p21.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31834916..31839761)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31687976..31692820)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31802693..31807538)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter of HSPA1A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31783959-31784528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31784529-31785098 Neighboring gene heat shock protein family A (Hsp70) member 1A Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31789548-31790747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31794443-31795254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795278-31795907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795908-31796536 Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31801830-31802528 Neighboring gene small nucleolar RNA, C/D box 48 Neighboring gene small nucleolar RNA, C/D box 52 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31830779-31831404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31831405-31832028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31832029-31832653 Neighboring gene neuraminidase 1 Neighboring gene solute carrier family 44 member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31838055-31838988 Neighboring gene EHMT2 and SLC44A4 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease. Partanen J, et al. Tissue Antigens, 1993 Jan. PMID 8096093
  2. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation. Xuan Y, et al. Cell Death Dis, 2019 Sep 18. PMID 31534128, Free PMC Article
  3. Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population. Pan Q, et al. Genet Mol Res, 2012 Dec 17. PMID 23079975
  4. Common genetic variation and the control of HIV-1 in humans. Fellay J, et al. PLoS Genet, 2009 Dec. PMID 20041166, Free PMC Article
  5. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Weinmann L, et al. Cell, 2009 Feb 6. PMID 19167051

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
    Title: Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
  2. Single nucleotide polymorphisms at C6orf48, BAT2 and ZBTB12 are associated with estrogen receptor positive breast cancer in the Chinese Han population.
    Title: Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • protein G8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_160945.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762
    Related
    ENST00000648677.1

  2. NR_160946.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762
    Related
    ENST00000375642.6

  3. NR_160947.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762

  4. NR_160948.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762
    Related
    ENST00000614363.4

  5. NR_160949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762
    Related
    ENST00000375638.7

  6. NR_160950.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762

  7. NR_160951.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762

  8. NR_160952.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762
    Related
    ENST00000375635.6

  9. NR_160953.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671762

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    31834916..31839761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    3167531..3172376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3312163..3317005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    3082695..3087539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3090756..3095597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    31687976..31692820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040437.2: Suppressed sequence

    Description
    NM_001040437.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  2. NM_001040438.2: Suppressed sequence

    Description
    NM_001040438.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NM_001287482.1: Suppressed sequence

    Description
    NM_001287482.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  4. NM_001287483.1: Suppressed sequence

    Description
    NM_001287483.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  5. NM_001287484.1: Suppressed sequence

    Description
    NM_001287484.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  6. NM_001287485.1: Suppressed sequence

    Description
    NM_001287485.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  7. NM_001287486.1: Suppressed sequence

    Description
    NM_001287486.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  8. NM_001287487.1: Suppressed sequence

    Description
    NM_001287487.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  9. NM_001287488.1: Suppressed sequence

    Description
    NM_001287488.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  10. NM_016947.1: Suppressed sequence

    Description
    NM_016947.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
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