PNPLA2 patatin like phospholipase domain containing 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PNPLA2provided by VGNC
Official Full Name: patatin like phospholipase domain containing 2provided by VGNC
Primary source: VGNC:VGNC:33091
See related: BGD:BT11983; Ensembl:ENSBTAG00000005144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ATGL
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (50548339..50553115, complement)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.
Title: Bovine adipose triglyceride lipase is not altered and adipocyte fatty acid-binding protein is increased by dietary flaxseed.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: patatin-like phospholipase domain-containing protein 2

Names: adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; iPLA2-zeta

NP_001039470.1

EC 3.1.1.3

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046005.2 → NP_001039470.1 patatin-like phospholipase domain-containing protein 2

See identical proteins and their annotated locations for NP_001039470.1

Status: PROVISIONAL

Source sequence(s)

BC112803

UniProtKB/Swiss-Prot

Q2KI18

UniProtKB/TrEMBL

C1K6G4, D6BQM3

Related

ENSBTAP00000029866.2, ENSBTAT00000029870.4

Conserved Domains (1) summary

cd07220
Location:5 → 252

Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2