TAS2R7 taste 2 receptor member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R7provided by HGNC
Official Full Name: taste 2 receptor member 7provided by HGNC
Primary source: HGNC:HGNC:14913
See related: Ensembl:ENSG00000121377 MIM:604793; AllianceGenome:HGNC:14913
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R7; TRB4
Summary: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 12p13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (10801532..10802627, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (10674613..10675708, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (10954131..10955226, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TAS2R7 may act as a metal cation receptor mediating bitterness of divalent and trivalent salts.
Title: Metal Ions Activate the Human Taste Receptor TAS2R7.
TAS2R7 is a receptor for bitter tasting salts.
Title: The human bitter taste receptor TAS2R7 facilitates the detection of bitter salts.
Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Galpha16/gust44/pcDNA3.1 (+) Cells.
Title: Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells.
Similar to majority of the Class A GPCRs, extracellular loop 2 in T2R7 plays a significant role in agonist binding and activation.
Title: Plasticity of the ligand binding pocket in the bitter taste receptor T2R7.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TAS2R7__5213 (e-PCR)
- UniSTS:464590

NoName (e-PCR)
- UniSTS:480718

NoName (e-PCR)
- UniSTS:485587

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 7

Names: taste receptor, family B, member 4; taste receptor, type 2, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023919.2 → NP_076408.1 taste receptor type 2 member 7

See identical proteins and their annotated locations for NP_076408.1

Status: REVIEWED

Source sequence(s)

BC069091, BC093992

Consensus CDS

CCDS8631.1

UniProtKB/Swiss-Prot

Q645Y1, Q9NYW3

UniProtKB/TrEMBL

Q50KV5

Related

ENSP00000240687.2, ENST00000240687.2

Conserved Domains (1) summary

cd15023
Location:7 → 297

7tm_TAS2R7-like; mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G protein-coupled receptor superfamily