U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 [ Bos taurus (domestic cattle) ]

Gene ID: 508355, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ITIH3provided by VGNC
Official Full Name
inter-alpha-trypsin inhibitor heavy chain 3provided by VGNC
Primary source
VGNC:VGNC:30335
See related
BGD:BT27694; Ensembl:ENSBTAG00000007846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ITIH3 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (48078022..48091969, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene NIMA related kinase 4

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. Huang L, et al. J Biol Chem, 1993 Dec 15. PMID 7504674
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
inter-alpha-trypsin inhibitor heavy chain H3
Names
ITI heavy chain H3
ITI-HC3
inter-alpha (globulin) inhibitor H3
inter-alpha-inhibitor heavy chain 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101898.2 → NP_001095368.1  inter-alpha-trypsin inhibitor heavy chain H3 precursor

    See identical proteins and their annotated locations for NP_001095368.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151419
    UniProtKB/Swiss-Prot
    A7MB92, P56652, Q0V8M9
    UniProtKB/TrEMBL
    A0AAA9RYN1
    Related
    ENSBTAP00000010322.5, ENSBTAT00000010322.6
    Conserved Domains (4) summary
    smart00609
    Location:29 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:281 → 462
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:47 → 630
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:685 → 872
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    48078022..48091969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982534.2 → XP_024838302.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RYN1
    Conserved Domains (3) summary
    smart00609
    Location:29 → 158
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:281 → 462
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:684 → 811
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56652.2 GenPept UniProtKB/Swiss-Prot:P56652

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.