TAS2R1 taste 2 receptor member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R1provided by HGNC
Official Full Name: taste 2 receptor member 1provided by HGNC
Primary source: HGNC:HGNC:14909
See related: Ensembl:ENSG00000169777 MIM:604796; AllianceGenome:HGNC:14909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R1; TRB7
Summary: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 5p15.31-p15.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (9627347..9903876, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (9567134..9843682, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (9627459..9903988, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.
Title: TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.
The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.
Title: The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.
TAS2R agonists block signaling downstream of phosphatidylinositol 3-kinase
Title: Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.
Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes
Title: Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization.
Title: TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1.
Title: Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Title: Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
The ligand binding pocket in T2R1 is present on the extracellular surface of the receptor, and is formed by the transmembrane helices 1, 2, 3 and 7 and with extracellular loops 1 and 2 forming a cap like structure on the binding pocket.
Title: Bitter taste receptor T2R1 is activated by dipeptides and tripeptides.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A genome-wide linkage and association scan reveals novel loci for autism.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide linkage and association scan reveals novel loci for autism. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480624

NoName (e-PCR)
- UniSTS:485625

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 1

Names: taste receptor, family B, member 7; taste receptor, type 2, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386348.1 → NP_001373277.1 taste receptor type 2 member 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC026787, AC034214, AC091958

UniProtKB/TrEMBL

Q50L07

Conserved Domains (1) summary

cd15016
Location:1 → 249

7tm_TAS2R1; mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily
NM_019599.3 → NP_062545.1 taste receptor type 2 member 1 isoform 1

See identical proteins and their annotated locations for NP_062545.1

Status: REVIEWED

Source sequence(s)

AC034214

Consensus CDS

CCDS3876.1

UniProtKB/Swiss-Prot

Q646G8, Q9NYW7

UniProtKB/TrEMBL

Q502V6

Related

ENSP00000371932.2, ENST00000382492.4

Conserved Domains (1) summary

pfam05296
Location:1 → 296

TAS2R; Taste receptor protein (TAS2R)