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LATS2 large tumor suppressor kinase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 508208, updated on 4-Oct-2024

Summary

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Official Symbol
LATS2provided by VGNC
Official Full Name
large tumor suppressor kinase 2provided by VGNC
Primary source
VGNC:VGNC:30801
See related
BGD:BT16267; Ensembl:ENSBTAG00000014406
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See LATS2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (35649270..35700350)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene Sin3A associated protein 18 Neighboring gene mitochondrial import receptor subunit TOM6 homolog pseudogene Neighboring gene exportin 4 Neighboring gene EEF1A lysine methyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. miR-497 regulates fatty acid synthesis via LATS2 in bovine mammary epithelial cells. Chen Z, et al. Food Funct, 2020 Oct 21. PMID 32935676
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-497 regulates fatty acid synthesis via LATS2 in bovine mammary epithelial cells.
    Title: miR-497 regulates fatty acid synthesis via LATS2 in bovine mammary epithelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase LATS2
Names
LATS, large tumor suppressor, homolog 2
XP_024855860.1
XP_024855861.1
XP_024855862.1
XP_024855863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35649270..35700350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000093.2 → XP_024855861.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    E1B9F9
    Conserved Domains (4) summary
    cd14398
    Location:97 → 137
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam04803
    Location:519 → 596
    Cor1; Cor1/Xlr/Xmr conserved region
    cl21453
    Location:592 → 972
    PKc_like; Protein Kinases, catalytic domain
    cl26464
    Location:147 → 526
    Atrophin-1; Atrophin-1 family

  2. XM_025000094.2 → XP_024855862.1  serine/threonine-protein kinase LATS2 isoform X2

    Conserved Domains (4) summary
    cd14398
    Location:97 → 137
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam04803
    Location:519 → 596
    Cor1; Cor1/Xlr/Xmr conserved region
    cl21453
    Location:592 → 851
    PKc_like; Protein Kinases, catalytic domain
    cl26464
    Location:147 → 526
    Atrophin-1; Atrophin-1 family

  3. XM_025000092.2 → XP_024855860.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    E1B9F9
    Related
    ENSBTAP00000019161.5, ENSBTAT00000019161.6
    Conserved Domains (4) summary
    cd14398
    Location:97 → 137
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    pfam04803
    Location:519 → 596
    Cor1; Cor1/Xlr/Xmr conserved region
    cl21453
    Location:592 → 972
    PKc_like; Protein Kinases, catalytic domain
    cl26464
    Location:147 → 526
    Atrophin-1; Atrophin-1 family

  4. XM_025000095.2 → XP_024855863.1  serine/threonine-protein kinase LATS2 isoform X3

    Conserved Domains (4) summary
    pfam04803
    Location:408 → 485
    Cor1; Cor1/Xlr/Xmr conserved region
    cl21453
    Location:481 → 861
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:1 → 26
    UBA_like_SF; UBA domain-like superfamily
    cl26464
    Location:36 → 415
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_003037539.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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Research Materials