Nt5c 5',3'-nucleotidase, cytosolic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nt5cprovided by MGI
Official Full Name: 5',3'-nucleotidase, cytosolicprovided by MGI
Primary source: MGI:MGI:1354954
See related: Ensembl:ENSMUSG00000020736 AllianceGenome:MGI:1354954
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnt; Dnt1; Umph2; Umph-2
Summary: Enables IMP 5'-nucleotidase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleoside monophosphate catabolic process. Acts upstream of or within deoxyribonucleotide catabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 50.2), colon adult (RPKM 41.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115381251..115382659, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115490420..115492070, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine nucleotide binding	IEA Inferred from Electronic Annotation more info
enables pyrimidine nucleotide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in allantoin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dCMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dUMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within deoxyribonucleotide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine deoxyribonucleotide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine deoxyribonucleotide catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5'(3')-deoxyribonucleotidase, cytosolic type

Names: 5' nucleotidase, deoxy (pyrimidine), cytosolic type C; cytosolic 5',3'-pyrimidine nucleotidase; dNT-1; deoxy-5'-nucleotidase 1; uridine monophosphatase 2

NP_001404571.1

EC 3.1.3.5

NP_001404572.1

EC 3.1.3.5

NP_056622.1

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417642.1 → NP_001404571.1 5'(3')-deoxyribonucleotidase, cytosolic type isoform 2

Status: VALIDATED

Source sequence(s)

AL645470
NM_001417643.1 → NP_001404572.1 5'(3')-deoxyribonucleotidase, cytosolic type isoform 3

Status: VALIDATED

Source sequence(s)

AL645470

UniProtKB/TrEMBL

A2A9X5

Related

ENSMUSP00000102140.2, ENSMUST00000106530.8
NM_015807.2 → NP_056622.1 5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

See identical proteins and their annotated locations for NP_056622.1

Status: VALIDATED

Source sequence(s)

AL645470

Consensus CDS

CCDS25637.1

UniProtKB/Swiss-Prot

Q9JM14

Related

ENSMUSP00000021082.7, ENSMUST00000021082.7

Conserved Domains (1) summary

cl21460
Location:5 → 196

HAD_like; Haloacid Dehalogenase-like Hydrolases