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Atp9b ATPase, class II, type 9B [ Mus musculus (house mouse) ]

Gene ID: 50771, updated on 17-Aug-2024

Summary

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Official Symbol
Atp9bprovided by MGI
Official Full Name
ATPase, class II, type 9Bprovided by MGI
Primary source
MGI:MGI:1354757
See related
Ensembl:ENSMUSG00000024566 AllianceGenome:MGI:1354757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IIb; MMR; Atpc2b
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in several structures, including adrenal gland; alimentary system; liver; nervous system; and thymus. Orthologous to human ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 29.2), thymus adult (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 53.9 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80777356..80977291, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80734141..80934081, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41790 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Neighboring gene predicted gene, 52342 Neighboring gene STARR-positive B cell enhancer mm9_chr18:80888627-80888928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:80935003-80935320 Neighboring gene STARR-seq mESC enhancer starr_45180 Neighboring gene STARR-positive B cell enhancer ABC_E7617 Neighboring gene STARR-seq mESC enhancer starr_45183 Neighboring gene spalt like transcription factor 3 Neighboring gene predicted gene 27239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel receptor on allograft (H-2d)-induced macrophage (H-2b) toward an allogeneic major histocompatibility complex class I molecule, H-2Dd, in mice. Tashiro-Yamaji J, et al. Microbiol Immunol, 2006. PMID 16490928
  2. Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer. Tosti E, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35688320, Free PMC Article
  3. Highly conserved non-coding sequences and the 18q critical region for short stature: a common mechanism of disease? Rizzolio F, et al. PLoS One, 2008 Jan 23. PMID 18213369, Free PMC Article
  4. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Paulusma CC, et al. Biochim Biophys Acta, 2005 Jun 30. PMID 15919184
  5. Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. Schauwecker PE, et al. J Comp Neurol, 2004 Sep 6. PMID 15281082

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.
    Title: Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable phospholipid-transporting ATPase IIB
Names
ATPase 9B, class II
ATPase 9B, p type
ATPase, class 2, member b
macrophage MHC receptor
NP_001188498.1
NP_056620.2
XP_006526569.1
XP_006526570.1
XP_030106388.1
XP_030106389.1
XP_030106390.1
XP_030106391.1
XP_030106392.1
XP_030106393.1
XP_030106394.1
XP_036017094.1
XP_036017096.1
XP_036017097.1
XP_036017098.1
XP_036017099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201569.1 → NP_001188498.1  probable phospholipid-transporting ATPase IIB isoform 1

    See identical proteins and their annotated locations for NP_001188498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK166562, BC079626
    Consensus CDS
    CCDS89288.1
    UniProtKB/Swiss-Prot
    P98195, Q68FM3, Q99LI3
    UniProtKB/TrEMBL
    D3YV00
    Related
    ENSMUSP00000089394.5, ENSMUST00000091790.5
    Conserved Domains (6) summary
    TIGR01652
    Location:130 → 1144
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:187 → 425
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:577 → 659
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:123 → 180
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:899 → 1138
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:866 → 894
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_015805.3 → NP_056620.2  probable phospholipid-transporting ATPase IIB isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK030485, AK166562, BC079626
    Consensus CDS
    CCDS29370.1
    UniProtKB/Swiss-Prot
    P98195, Q68FM3, Q99LI3
    UniProtKB/TrEMBL
    A0A286YCV0
    Related
    ENSMUSP00000153157.2, ENSMUST00000225980.2
    Conserved Domains (1) summary
    cd07541
    Location:131 → 1055
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80777356..80977291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526507.4 → XP_006526570.1  probable phospholipid-transporting ATPase IIB isoform X2

    UniProtKB/Swiss-Prot
    P98195, Q68FM3, Q99LI3
    Conserved Domains (2) summary
    cd07541
    Location:131 → 1076
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:596 → 680
    Cation_ATPase; Cation transport ATPase (P-type)

  2. XM_006526506.4 → XP_006526569.1  probable phospholipid-transporting ATPase IIB isoform X1

    UniProtKB/Swiss-Prot
    P98195, Q68FM3, Q99LI3
    Conserved Domains (2) summary
    cd07541
    Location:131 → 1076
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:596 → 680
    Cation_ATPase; Cation transport ATPase (P-type)

  3. XM_036161201.1 → XP_036017094.1  probable phospholipid-transporting ATPase IIB isoform X4

    Conserved Domains (2) summary
    cd07541
    Location:1 → 807
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:300 → 411
    Cation_ATPase; Cation transport ATPase (P-type)

  4. XM_030250528.2 → XP_030106388.1  probable phospholipid-transporting ATPase IIB isoform X3

    Conserved Domains (2) summary
    cd07541
    Location:11 → 825
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:345 → 429
    Cation_ATPase; Cation transport ATPase (P-type)

  5. XM_030250532.2 → XP_030106392.1  probable phospholipid-transporting ATPase IIB isoform X5

    Conserved Domains (2) summary
    pfam13246
    Location:216 → 300
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 696
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  6. XM_030250534.2 → XP_030106394.1  probable phospholipid-transporting ATPase IIB isoform X6

    Conserved Domains (2) summary
    pfam13246
    Location:155 → 266
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 662
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  7. XM_030250531.2 → XP_030106391.1  probable phospholipid-transporting ATPase IIB isoform X5

    Conserved Domains (2) summary
    pfam13246
    Location:216 → 300
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 696
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  8. XM_030250533.1 → XP_030106393.1  probable phospholipid-transporting ATPase IIB isoform X6

    Conserved Domains (2) summary
    pfam13246
    Location:155 → 266
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 662
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  9. XM_030250529.2 → XP_030106389.1  probable phospholipid-transporting ATPase IIB isoform X4

    Conserved Domains (2) summary
    cd07541
    Location:1 → 807
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:300 → 411
    Cation_ATPase; Cation transport ATPase (P-type)

  10. XM_030250530.1 → XP_030106390.1  probable phospholipid-transporting ATPase IIB isoform X5

    Conserved Domains (2) summary
    pfam13246
    Location:216 → 300
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 696
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  11. XM_036161203.1 → XP_036017096.1  probable phospholipid-transporting ATPase IIB isoform X6

    Conserved Domains (2) summary
    pfam13246
    Location:155 → 266
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 662
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  12. XM_036161205.1 → XP_036017098.1  probable phospholipid-transporting ATPase IIB isoform X7

    Conserved Domains (2) summary
    pfam13246
    Location:120 → 231
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 627
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  13. XM_036161206.1 → XP_036017099.1  probable phospholipid-transporting ATPase IIB isoform X7

    Conserved Domains (2) summary
    pfam13246
    Location:120 → 231
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 627
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  14. XM_036161204.1 → XP_036017097.1  probable phospholipid-transporting ATPase IIB isoform X6

    Conserved Domains (2) summary
    pfam13246
    Location:155 → 266
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1 → 662
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98195.4 GenPept UniProtKB/Swiss-Prot:P98195

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