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Fbxl17 F-box and leucine-rich repeat protein 17 [ Mus musculus (house mouse) ]

Gene ID: 50758, updated on 18-Sep-2024

Summary

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Official Symbol
Fbxl17provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 17provided by MGI
Primary source
MGI:MGI:1354704
See related
Ensembl:ENSMUSG00000023965 AllianceGenome:MGI:1354704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx13; Fbxo13; 6330576B01Rik; C130023C01Rik
Summary
Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; entrainment of circadian clock by photoperiod; and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in inferior colliculus; midbrain ventricular layer; and ventral grey horn. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxl17 in Genome Data Viewer
Location:
17 E1.1; 17 32.68 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (63352944..63811179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (63045949..63504184, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ephrin A5 Neighboring gene predicted gene, 52303 Neighboring gene predicted gene, 46583 Neighboring gene VISTA enhancer mm1538 Neighboring gene STARR-seq mESC enhancer starr_42966 Neighboring gene predicted gene, 34179 Neighboring gene STARR-seq mESC enhancer starr_42967 Neighboring gene predicted gene, 34324 Neighboring gene STARR-seq mESC enhancer starr_42968 Neighboring gene STARR-seq mESC enhancer starr_42969 Neighboring gene predicted gene, 53980 Neighboring gene predicted gene, 24730 Neighboring gene RIKEN cDNA 4930405O22 gene Neighboring gene predicted gene, 41607 Neighboring gene STARR-positive B cell enhancer ABC_E7551 Neighboring gene predicted gene 17228 Neighboring gene predicted gene, 18418 Neighboring gene STARR-seq mESC enhancer starr_42972 Neighboring gene STARR-seq mESC enhancer starr_42973 Neighboring gene peptidylprolyl isomerase A pseudogene 17_1026.1 Neighboring gene mitochondrial pyruvate carrier 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. Raducu M, et al. EMBO J, 2016 Jul 1. PMID 27234298, Free PMC Article
  2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
  3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 17
Names
F-box only protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015794.1 → NP_056609.1  F-box/LRR-repeat protein 17

    See identical proteins and their annotated locations for NP_056609.1

    Status: VALIDATED

    Source sequence(s)
    AC154192, AF176529, BX515367, CJ179644, CT025670
    Consensus CDS
    CCDS50162.1
    UniProtKB/Swiss-Prot
    B2RRC1, Q8BTC3, Q9QZN1
    Related
    ENSMUSP00000024761.7, ENSMUST00000024761.13
    Conserved Domains (3) summary
    cd09293
    Location:411 → 573
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362 → 387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321 → 368
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    63352944..63811179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160679.1 → XP_036016572.1  F-box/LRR-repeat protein 17 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:411 → 573
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362 → 387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321 → 366
    F-box-like

  2. XM_006524600.4 → XP_006524663.1  F-box/LRR-repeat protein 17 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:363 → 456
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362 → 387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321 → 366
    F-box-like

RNA

  1. XR_385343.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177143.2: Suppressed sequence

    Description
    NM_177143.2: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZN1.3 GenPept UniProtKB/Swiss-Prot:Q9QZN1

Gene LinkOut

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