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MCM8 minichromosome maintenance 8 homologous recombination repair factor [ Bos taurus (domestic cattle) ]

Gene ID: 507507, updated on 4-Oct-2024

Summary

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Official Symbol
MCM8provided by VGNC
Official Full Name
minichromosome maintenance 8 homologous recombination repair factorprovided by VGNC
Primary source
VGNC:VGNC:31314
See related
BGD:BT29635; Ensembl:ENSBTAG00000014623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MCM8 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (48120713..48166976)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized LOC112449307 Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA helicase MCM8
Names
minichromosome maintenance complex component 8
NP_001179965.1
XP_005214665.1
XP_010809724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193036.1 → NP_001179965.1  DNA helicase MCM8

    See identical proteins and their annotated locations for NP_001179965.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000013
    UniProtKB/Swiss-Prot
    E1BPX4
    UniProtKB/TrEMBL
    A0AAA9TRA5
    Related
    ENSBTAP00000079023.1, ENSBTAT00000119412.1
    Conserved Domains (3) summary
    cd00009
    Location:411 → 569
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1241
    Location:88 → 813
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
    pfam14551
    Location:91 → 215
    MCM_N; MCM N-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    48120713..48166976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010811422.4 → XP_010809724.1  DNA helicase MCM8 isoform X1

    See identical proteins and their annotated locations for XP_010809724.1

    UniProtKB/TrEMBL
    A0AAA9TRA5, A0AAF6Z0E4
    Conserved Domains (1) summary
    COG1241
    Location:88 → 829
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

  2. XM_005214608.5 → XP_005214665.1  DNA helicase MCM8 isoform X1

    See identical proteins and their annotated locations for XP_005214665.1

    UniProtKB/TrEMBL
    A0AAA9TRA5, A0AAF6Z0E4
    Related
    ENSBTAP00000019471.6, ENSBTAT00000019471.7
    Conserved Domains (1) summary
    COG1241
    Location:88 → 829
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1BPX4.2 GenPept UniProtKB/Swiss-Prot:E1BPX4

Gene LinkOut

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