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SHMT2 serine hydroxymethyltransferase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 507197, updated on 4-Oct-2024

Summary

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Official Symbol
SHMT2provided by VGNC
Official Full Name
serine hydroxymethyltransferase 2provided by VGNC
Primary source
VGNC:VGNC:34604
See related
BGD:BT30382; Ensembl:ENSBTAG00000031500
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SHMT2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56208140..56216259, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene NDUFA4 mitochondrial complex associated like 2 Neighboring gene neurexophilin 4 Neighboring gene LDL receptor related protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC128707

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to type I interferon IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRISC complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase, mitochondrial
Names
SHMT
glycine hydroxymethyltransferase
serine hydroxymethyltransferase 2 (mitochondrial)
serine methylase
NP_001029454.1
XP_005206590.1
XP_010803440.1
XP_010803441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034282.1 → NP_001029454.1  serine hydroxymethyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001029454.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103242
    UniProtKB/Swiss-Prot
    Q3SZ20
    UniProtKB/TrEMBL
    A0AAF6ZD84
    Related
    ENSBTAP00000099164.1, ENSBTAT00000106569.1
    Conserved Domains (2) summary
    PLN03226
    Location:38 → 502
    PLN03226; serine hydroxymethyltransferase; Provisional
    pfam00464
    Location:49 → 448
    SHMT; Serine hydroxymethyltransferase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56208140..56216259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206533.1 → XP_005206590.1  serine hydroxymethyltransferase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005206590.1

    UniProtKB/TrEMBL
    A0AAF6ZD84
    Related
    ENSBTAP00000038059.3, ENSBTAT00000038244.4
    Conserved Domains (1) summary
    PLN03226
    Location:17 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. XM_010805139.4 → XP_010803441.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_010803441.1

    Conserved Domains (1) summary
    cl18945
    Location:1 → 287
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. XM_010805138.4 → XP_010803440.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_010803440.1

    Conserved Domains (1) summary
    cl18945
    Location:1 → 287
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SZ20.1 GenPept UniProtKB/Swiss-Prot:Q3SZ20

Gene LinkOut

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