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LARGE1 LARGE xylosyl- and glucuronyltransferase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 506466, updated on 10-Oct-2024

Summary

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Official Symbol
LARGE1provided by VGNC
Official Full Name
LARGE xylosyl- and glucuronyltransferase 1provided by VGNC
Primary source
VGNC:VGNC:54444
See related
BGD:BT16788; Ensembl:ENSBTAG00000021953
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See LARGE1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (71806170..72416116, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446723 Neighboring gene protein HP-20 homolog Neighboring gene uncharacterized LOC101905163 Neighboring gene transfer RNA arginine (anticodon CCU)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables xylosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
xylosyl- and glucuronyltransferase LARGE1
NP_001192517.1
XP_005206837.1
XP_024847258.1
XP_059742187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205588.1 → NP_001192517.1  xylosyl- and glucuronyltransferase LARGE1

    See identical proteins and their annotated locations for NP_001192517.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    A0AAA9TNJ8, E1BDI0
    Related
    ENSBTAP00000029269.6, ENSBTAT00000029269.7
    Conserved Domains (3) summary
    cd06431
    Location:138 → 417
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:136 → 386
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:473 → 742
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    71806170..72416116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206780.5 → XP_005206837.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

    See identical proteins and their annotated locations for XP_005206837.1

    UniProtKB/TrEMBL
    A0AAA9TNJ8, E1BDI0
    Conserved Domains (3) summary
    cd06431
    Location:138 → 417
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:136 → 386
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:473 → 742
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

  2. XM_059886204.1 → XP_059742187.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

    UniProtKB/TrEMBL
    E1BDI0

  3. XM_024991490.2 → XP_024847258.1  xylosyl- and glucuronyltransferase LARGE1 isoform X2

    UniProtKB/TrEMBL
    A0AAA9TNJ8
    Conserved Domains (2) summary
    cd06431
    Location:35 → 314
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    pfam13896
    Location:370 → 639
    Glyco_transf_49; Glycosyl-transferase for dystroglycan
Nucleotide Protein Strain
Heading Accession and Version

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