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ITSN2 intersectin 2 [ Homo sapiens (human) ]

Gene ID: 50618, updated on 3-Apr-2024

Summary

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Official Symbol
ITSN2provided by HGNC
Official Full Name
intersectin 2provided by HGNC
Primary source
HGNC:HGNC:6184
See related
Ensembl:ENSG00000198399 MIM:604464; AllianceGenome:HGNC:6184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWA; SWAP; SH3D1B; SH3P18; PRO2015
Summary
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ITSN2 in Genome Data Viewer
Location:
2p23.3
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24202864..24361368, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24237561..24395986, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24425733..24583405, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene uncharacterized LOC105374328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15429 Neighboring gene family with sequence similarity 228 member A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:24475575-24476774 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11230 Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 9937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24623030-24623530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625230-24625736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24625737-24626243 Neighboring gene uncharacterized LOC105374329 Neighboring gene NANOG hESC enhancer GRCh37_chr2:24679828-24680425 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904 Neighboring gene Sharpr-MPRA regulatory region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11232 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24714093-24714251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11233 Neighboring gene MPRA-validated peak3621 silencer Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, 5S ribosomal pseudogene 88

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of human Intersectin-2L C2 domain. Zhang W, et al. Biochem Biophys Res Commun, 2013 Feb 1. PMID 23274495
  2. Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain. Seifert M, et al. Oncol Rep, 2007 May. PMID 17390067
  3. ITSN2L Interacts with and Negatively Regulates RABEP1. Yang X, et al. Int J Mol Sci, 2015 Nov 27. PMID 26633357, Free PMC Article
  4. Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. Novokhatska O, et al. PLoS One, 2013. PMID 23936226, Free PMC Article
  5. Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation. Ding X, et al. BMB Rep, 2012 Mar. PMID 22449706

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
    Title: Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
  2. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis.
    Title: ITSN2L Interacts with and Negatively Regulates RABEP1.
  3. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins.
    Title: Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.
  4. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
    Title: Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
  5. The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42.
    Title: Crystal structure of human Intersectin-2L C2 domain.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
  7. ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane.
    Title: Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.
  8. We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2).
    Title: The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.
  9. ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function.
    Title: Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.
  10. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2.
    Title: Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
EBI GWAS Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of intersectin 2 (ITSN2; SH3P18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in intracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intersectin-2
Names
SH3 domain-containing protein 1B
SH3P18-like WASP-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029516.1 RefSeqGene

    Range
    4993..162665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348181.2 → NP_001335110.1  intersectin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008073, AC009228
    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (12) summary
    cd08375
    Location:1541 → 1675
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:1 → 93
    EH; Eps15 homology domain
    cd11988
    Location:745 → 801
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1200 → 1380
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:76 → 168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:801 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1398 → 1540
    PH_13; Pleckstrin homology domain
    cl26511
    Location:332 → 742
    Neuromodulin_N; Gap junction protein N-terminal region

  2. NM_001348182.2 → NP_001335111.1  intersectin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008073, AC009228
    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (12) summary
    cd08375
    Location:1515 → 1649
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:719 → 775
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862 → 913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945 → 996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1017 → 1075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1090 → 1143
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1174 → 1354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16617
    Location:775 → 862
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1372 → 1514
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377 → 719
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27427
    Location:126 → 200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  3. NM_001348183.2 → NP_001335112.1  intersectin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC009228
    UniProtKB/TrEMBL
    Q53TK4
    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:732 → 788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875 → 926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:958 → 1009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1030 → 1088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1103 → 1156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90 → 182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788 → 875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:377 → 727
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001348184.2 → NP_001335113.1  intersectin-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC009228
    UniProtKB/TrEMBL
    Q53TK4
    Conserved Domains (9) summary
    smart00027
    Location:1 → 93
    EH; Eps15 homology domain
    cd11988
    Location:718 → 774
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:861 → 912
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:944 → 995
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1016 → 1074
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1089 → 1142
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:76 → 168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:774 → 861
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:363 → 713
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001348185.2 → NP_001335114.1  intersectin-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC009228
    UniProtKB/TrEMBL
    Q53TK4
    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:746 → 802
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:889 → 940
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:972 → 1023
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1044 → 1102
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1117 → 1170
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam16617
    Location:802 → 889
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl26511
    Location:346 → 743
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27427
    Location:126 → 200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  6. NM_001348186.2 → NP_001335115.1  intersectin-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009228
    UniProtKB/TrEMBL
    Q53TK4
    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:719 → 775
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862 → 913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945 → 996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1017 → 1075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1090 → 1143
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam16617
    Location:775 → 862
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:377 → 719
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27427
    Location:126 → 200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  7. NM_006277.3 → NP_006268.2  intersectin-2 isoform 1

    See identical proteins and their annotated locations for NP_006268.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as ITSN2-L, encodes the longest isoform (1).
    Source sequence(s)
    AC008073, AC009228, AF182198, BC146779, DA382952
    Consensus CDS
    CCDS1710.2
    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    UniProtKB/TrEMBL
    A6H8W8
    Related
    ENSP00000347244.4, ENST00000355123.9
    Conserved Domains (11) summary
    PTZ00121
    Location:346 → 756
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1555 → 1689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:759 → 815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902 → 953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:985 → 1036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1057 → 1115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1130 → 1183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1214 → 1394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1412 → 1555
    PH_13; Pleckstrin homology domain
    cd21577
    Location:91 → 184
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  8. NM_019595.4 → NP_062541.3  intersectin-2 isoform 3

    See identical proteins and their annotated locations for NP_062541.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 3) that lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC008073, AC009228, AF182198, AF182199, BC146779, DA382952
    Consensus CDS
    CCDS1711.2
    UniProtKB/TrEMBL
    A6H8W8
    Related
    ENSP00000354561.2, ENST00000361999.7
    Conserved Domains (12) summary
    cd08375
    Location:1528 → 1662
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:732 → 788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875 → 926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:958 → 1009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1030 → 1088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1103 → 1156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1187 → 1367
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788 → 875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1385 → 1527
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377 → 727
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_147152.3 → NP_671494.2  intersectin-2 isoform 2

    See identical proteins and their annotated locations for NP_671494.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as ITSN2-S1, has an alternate 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC009228, AF038189, AF182199, DA382952
    Consensus CDS
    CCDS46230.1
    UniProtKB/TrEMBL
    Q53TK4
    Related
    ENSP00000384499.3, ENST00000406921.7
    Conserved Domains (13) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:759 → 815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902 → 953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:985 → 1036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1057 → 1115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1130 → 1183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00052
    Location:248 → 314
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam08496
    Location:692 → 757
    Peptidase_S49_N; Peptidase family S49 N-terminal
    pfam13499
    Location:249 → 306
    EF-hand_7; EF-hand domain pair
    pfam13868
    Location:387 → 741
    TPH; Trichohyalin-plectin-homology domain
    pfam16617
    Location:815 → 902
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:454 → 465
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:379 → 484
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    24202864..24361368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444586.1 → XP_047300542.1  intersectin-2 isoform X2

  2. XM_047444582.1 → XP_047300538.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4

  3. XM_024452933.2 → XP_024308701.1  intersectin-2 isoform X3

    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (12) summary
    cd08375
    Location:1542 → 1676
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:746 → 802
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:889 → 940
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:972 → 1023
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1044 → 1102
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1117 → 1170
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1201 → 1381
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:802 → 889
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1399 → 1541
    PH_13; Pleckstrin homology domain
    cl26511
    Location:346 → 743
    Neuromodulin_N; Gap junction protein N-terminal region

  4. XM_024452934.2 → XP_024308702.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (12) summary
    cd08375
    Location:1528 → 1662
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:732 → 788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875 → 926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:958 → 1009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1030 → 1088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1103 → 1156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1187 → 1367
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788 → 875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1385 → 1527
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377 → 727
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_024452931.2 → XP_024308699.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (11) summary
    PTZ00121
    Location:346 → 756
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1555 → 1689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:759 → 815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902 → 953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:985 → 1036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1057 → 1115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1130 → 1183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1214 → 1394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1412 → 1555
    PH_13; Pleckstrin homology domain
    cd21577
    Location:91 → 184
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  6. XM_047444584.1 → XP_047300540.1  intersectin-2 isoform X4

  7. XM_047444583.1 → XP_047300539.1  intersectin-2 isoform X2

  8. XM_024452930.2 → XP_024308698.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4
    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (11) summary
    PTZ00121
    Location:346 → 756
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1555 → 1689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:759 → 815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902 → 953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:985 → 1036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1057 → 1115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1130 → 1183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1214 → 1394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1412 → 1555
    PH_13; Pleckstrin homology domain
    cd21577
    Location:91 → 184
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  9. XM_024452932.2 → XP_024308700.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A6H8W8
    Conserved Domains (12) summary
    cd08375
    Location:1541 → 1675
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:1 → 93
    EH; Eps15 homology domain
    cd11988
    Location:745 → 801
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1200 → 1380
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:76 → 168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:801 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1398 → 1540
    PH_13; Pleckstrin homology domain
    cl26511
    Location:332 → 742
    Neuromodulin_N; Gap junction protein N-terminal region

  10. XM_047444585.1 → XP_047300541.1  intersectin-2 isoform X4

  11. XM_024452937.2 → XP_024308705.1  intersectin-2 isoform X9

    Conserved Domains (9) summary
    cd08375
    Location:787 → 921
    C2_Intersectin; C2 domain present in Intersectin
    cd11990
    Location:134 → 185
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:217 → 268
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:289 → 347
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:362 → 415
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:446 → 626
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16617
    Location:47 → 134
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:644 → 786
    PH_13; Pleckstrin homology domain
    cl17036
    Location:15 → 47
    SH3; Src Homology 3 domain superfamily

  12. XM_047444587.1 → XP_047300543.1  intersectin-2 isoform X5

  13. XM_047444590.1 → XP_047300546.1  intersectin-2 isoform X8

  14. XM_047444591.1 → XP_047300547.1  intersectin-2 isoform X8

  15. XM_047444588.1 → XP_047300544.1  intersectin-2 isoform X6

  16. XM_047444589.1 → XP_047300545.1  intersectin-2 isoform X7

  17. XM_047444592.1 → XP_047300548.1  intersectin-2 isoform X10

  18. XM_047444594.1 → XP_047300550.1  intersectin-2 isoform X12

  19. XM_047444593.1 → XP_047300549.1  intersectin-2 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    24237561..24395986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342321.1 → XP_054198296.1  intersectin-2 isoform X2

  2. XM_054342318.1 → XP_054198293.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4

  3. XM_054342319.1 → XP_054198294.1  intersectin-2 isoform X3

  4. XM_054342322.1 → XP_054198297.1  intersectin-2 isoform X2

  5. XM_054342317.1 → XP_054198292.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4

  6. XM_054342316.1 → XP_054198291.1  intersectin-2 isoform X1

    UniProtKB/Swiss-Prot
    O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9NZM3, Q9ULG4

  7. XM_054342320.1 → XP_054198295.1  intersectin-2 isoform X4

  8. XM_054342329.1 → XP_054198304.1  intersectin-2 isoform X9

  9. XM_054342328.1 → XP_054198303.1  intersectin-2 isoform X9

  10. XM_054342323.1 → XP_054198298.1  intersectin-2 isoform X5

  11. XM_054342326.1 → XP_054198301.1  intersectin-2 isoform X8

  12. XM_054342327.1 → XP_054198302.1  intersectin-2 isoform X8

  13. XM_054342324.1 → XP_054198299.1  intersectin-2 isoform X6

  14. XM_054342325.1 → XP_054198300.1  intersectin-2 isoform X7

  15. XM_054342330.1 → XP_054198305.1  intersectin-2 isoform X10

  16. XM_054342332.1 → XP_054198307.1  intersectin-2 isoform X12

  17. XM_054342331.1 → XP_054198306.1  intersectin-2 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZM3.3 GenPept UniProtKB/Swiss-Prot:Q9NZM3

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