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MYL2 myosin light chain 2 [ Bos taurus (domestic cattle) ]

Gene ID: 505519, updated on 4-Oct-2024

Summary

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Official Symbol
MYL2provided by VGNC
Official Full Name
myosin light chain 2provided by VGNC
Primary source
VGNC:VGNC:31800
See related
BGD:BT27976; Ensembl:ENSBTAG00000018369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
MLC-2s/v
Orthologs
human mouse all
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Genomic context

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See MYL2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (54706768..54714509, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 63 Neighboring gene cut like homeobox 2 Neighboring gene PH domain containing endocytic trafficking adaptor 1 Neighboring gene SH2B adaptor protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC128326

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Names
MLC-2
MLC-2v
myosin, light chain 2, regulatory, cardiac, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035025.2 → NP_001030197.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform

    See identical proteins and their annotated locations for NP_001030197.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102914
    UniProtKB/Swiss-Prot
    Q3SZE5
    UniProtKB/TrEMBL
    A0A3Q1N6P5
    Related
    ENSBTAP00000024444.2, ENSBTAT00000024444.4
    Conserved Domains (2) summary
    COG5126
    Location:18 → 163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cl08302
    Location:28 → 86
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    54706768..54714509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005217753.4 → XP_005217810.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1

    See identical proteins and their annotated locations for XP_005217810.1

    UniProtKB/TrEMBL
    A0A3Q1N6P5, F1ME15
    Conserved Domains (1) summary
    COG5126
    Location:15 → 163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SZE5.1 GenPept UniProtKB/Swiss-Prot:Q3SZE5

Gene LinkOut

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Molecular Biology Databases
Research Materials