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osi orsai [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50459, updated on 2-Nov-2024

Summary

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Official Symbol
osiprovided by FlyBase
Official Full Name
orsaiprovided by FlyBase
Primary source
FLYBASE:FBgn0040985
Locus tag
Dmel_CG6115
See related
AllianceGenome:FB:FBgn0040985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH16758; CG6115; Dmel\CG6115
Summary
Involved in negative regulation of cellular respiration. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See osi in Genome Data Viewer
Location:
36B3-36B3; 2-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16887109..16887966, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16887109..16887966, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44392 Neighboring gene tweek Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
  2. Drosophila Gut Immune Pathway Suppresses Host Development-Promoting Effects of Acetic Acid Bacteria. Lee J, et al. Mol Cells, 2023 Oct 31. PMID 37853687, Free PMC Article
  3. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
  4. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article
  5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
orsai
Names
CG6115-PA
CG6115-PB
osi-PA
osi-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16887109..16887966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299072.1 → NP_001286001.1  orsai, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJG4
    Conserved Domains (1) summary
    cd20265
    Location:5 → 80
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

  2. NM_144321.3 → NP_652578.1  orsai, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652578.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJG4
    Related
    FBpp0080512
    Conserved Domains (1) summary
    cd20265
    Location:5 → 80
    Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJG4 Q9VJG4

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