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LRP4 LDL receptor related protein 4 [ Bos taurus (domestic cattle) ]

Gene ID: 504317, updated on 4-Oct-2024

Summary

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Official Symbol
LRP4provided by VGNC
Official Full Name
LDL receptor related protein 4provided by VGNC
Primary source
VGNC:VGNC:30992
See related
BGD:BT26059; Ensembl:ENSBTAG00000008429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
MEGF7
Orthologs
human mouse all
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Genomic context

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See LRP4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (76789246..76840794, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene uncharacterized LOC132342367 Neighboring gene microRNA mir-2319a Neighboring gene microRNA mir-2319b Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene uncharacterized LOC112441656 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4). Drögemüller C, et al. BMC Genet, 2007 Feb 23. PMID 17319939, Free PMC Article
  2. Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. Johnson EB, et al. Genomics, 2006 Nov. PMID 16963222
  3. Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle. Duchesne A, et al. Genomics, 2006 Nov. PMID 16859890
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. autosomal recessive loss-of-function mutations in Megf7/Lrp4 result in a form of syndactyly, mulefoot disease
    Title: Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease.
  2. identification of a doublet mutation in complete linkage disequilibrium with syndactyly in one gene of the critical interval: LRP4
    Title: Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle.
  3. 4 new LRP4 non-synonymous missense point mutations co-segregating in Holstein, German Simmental & Simmental-Charolais families represent independent mutations affecting different conserved protein domains.
    Title: Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 4
Names
low density lipoprotein receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077843.1 → NP_001071311.1  low-density lipoprotein receptor-related protein 4 precursor

    See identical proteins and their annotated locations for NP_001071311.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ462703
    UniProtKB/TrEMBL
    A0AAF6DLZ3, F1ML31, Q00KA9
    Related
    ENSBTAP00000082306.1, ENSBTAT00000102085.1
    Conserved Domains (9) summary
    smart00192
    Location:311 → 343
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:505 → 545
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:395 → 434
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:270 → 304
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1085 → 1123
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:70 → 105
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:1179 → 1219
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1313 → 1348
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:1085 → 1277
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    76789246..76840794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975054.2 → XP_024830822.1  low-density lipoprotein receptor-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DLZ3
    Conserved Domains (9) summary
    smart00192
    Location:311 → 343
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:505 → 545
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:395 → 434
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:270 → 304
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1085 → 1123
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:70 → 105
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:1179 → 1219
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1085 → 1277
    NHL; NHL repeat unit of beta-propeller proteins
    pfam14670
    Location:1313 → 1348
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version

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