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schlank schlank [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50392, updated on 2-Nov-2024

Summary

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Official Symbol
schlankprovided by FlyBase
Official Full Name
schlankprovided by FlyBase
Primary source
FLYBASE:FBgn0040918
Locus tag
Dmel_CG3576
See related
AllianceGenome:FB:FBgn0040918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CerS; CG15898; CG3576; Dlag1; DLag1; DLAG1; Dmel\CG3576; Iag1; l(1)G0061; l(1)G0365; l(1)G0489; lag1; Lag1; lon; Schlank
Summary
Enables sphingosine N-acyltransferase activity. Involved in several processes, including SREBP signaling pathway; ceramide biosynthetic process; and regulation of lipid metabolic process. Located in endoplasmic reticulum and nuclear inner membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; glial cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to several human genes including CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See schlank in Genome Data Viewer
Location:
5E3-5E4; 1-16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6257668..6267228, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6151701..6161261, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rabconnectin-3A Neighboring gene Spliceosomal protein on the X Neighboring gene Josephin domain containing Neighboring gene Spt6 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-5E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS. Voelzmann A, et al. Gene Expr Patterns, 2011 Dec. PMID 21907829
  2. Towards understanding regulation of energy homeostasis by ceramide synthases. Bauer R. Results Probl Cell Differ, 2010. PMID 20865380
  3. Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Li Y, et al. Gastroenterology, 2023 Nov. PMID 37541526, Free PMC Article
  4. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. Jung WH, et al. EMBO Rep, 2017 Jul. PMID 28507162, Free PMC Article
  5. Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. Voelzmann A, et al. FEBS Lett, 2016 Apr. PMID 26950647

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the homeodomain of Schlank is involved in the regulation of lipid metabolism in fat bodies; this regulation is independent of the catalytic lag1p motif of Schlank active site; Schlank homeodomain mediates nuclear localization.
    Title: Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif.
  2. Schlank is upregulated in the developing central (CNS) and peripheral nervous system (PNS). Co-staining experiments with neuronal and glial markers revealed specific expression of Schlank in glial and neuronal cells of the CNS and PNS.
    Title: Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS.
  3. Schlank encodes a conserved member of the Lass/CerS family of ceramide synthases , which contain a catalytic Lag1 motif and a homeobox transcription factor domain
    Title: Towards understanding regulation of energy homeostasis by ceramide synthases.
  4. results identify schlank (aka Lag1) as a new regulator of the balance between lipogenesis and lipolysis in Drosophila
    Title: Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingosine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine N-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
schlank
Names
CG3576-PA
CG3576-PB
Psc
longevity
longevity assurance gene 1
schlank-PA
schlank-PB
NP_652526.1
NP_727075.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6257668..6267228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167063.3 → NP_727075.1  schlank, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RN6, Q9W423
    Related
    FBpp0070898
    Conserved Domains (2) summary
    smart00724
    Location:135 → 334
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:75 → 131
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. NM_144269.4 → NP_652526.1  schlank, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RN6, Q9W423
    Related
    FBpp0070899
    Conserved Domains (2) summary
    smart00724
    Location:135 → 334
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:75 → 131
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W423 Q9W423

Gene LinkOut

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