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pkig protein kinase (cAMP-dependent, catalytic) inhibitor gamma [ Danio rerio (zebrafish) ]

Gene ID: 503808, updated on 18-Sep-2024

Summary

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Official Symbol
pkigprovided by ZNC
Official Full Name
protein kinase (cAMP-dependent, catalytic) inhibitor gammaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050302-97
See related
Ensembl:ENSDARG00000086471 AllianceGenome:ZFIN:ZDB-GENE-050302-97
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fl39e07
Summary
Predicted to enable cAMP-dependent protein kinase inhibitor activity. Predicted to be involved in negative regulation of cAMP-dependent protein kinase activity. Predicted to act upstream of or within negative regulation of protein kinase activity. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pkig in Genome Data Viewer
Location:
chromosome: 23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (25879396..25942859)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (25952855..26016318)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene hepatocyte nuclear factor 4, alpha Neighboring gene uncharacterized LOC137489129 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene uncharacterized LOC137489128 Neighboring gene adenosine deaminase Neighboring gene cellular communication network factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166156.3 → NP_001159628.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_001159628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CR318614, CR678304, EH550275
    UniProtKB/TrEMBL
    A0A8M1NSV2, E7F462
    Related
    ENSDARP00000107936.2, ENSDART00000124963.4
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 68
    PKI; cAMP-dependent protein kinase inhibitor

  2. NM_001309188.1 → NP_001296117.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_001296117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CR678304
    UniProtKB/TrEMBL
    A0A8M1NSV2, E7F462
    Related
    ENSDARP00000118275.1, ENSDART00000144769.2
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 68
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    25879396..25942859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395153.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    306624..307637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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